A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method

Figure 3

DSC thermogram after 1-day and 1-month stability (a) AT: PVPK30 (1 : 1), (b) AT: PVPK30 (2 : 3), (c) AT: PVP/VA S-630 (1 : 1), (d) AT: PVP/VA S-630 (2 : 3), (e) AT: HPMC AS (1 : 1), (f) AT: HPMC AS (2 : 3), (g) AT: POLOXAMER 407 (1 : 1), (h) AT: POLOXAMER 407 (2:3) (sample codes in thermogram: AMX—amoxicillin trihydrate, SL—SLS (sodium lauryl sulfate), PK—PVP k30, PVD10—film at initial time (drug + PVP k30 + SLS), PVP 24—film at 1 month (drug + PVP k30 + SLS), PVD20—film at initial time (drug + PVP k30 + SLS), PVP 20—film at 1 month (drug + PVP k30 + SLS), PV 630—PVP/VA S-630, PD10—film at initial time (drug + PVP/VA S-630 + SLS), VAD24—film at 1 month (drug + PVP/VA S-630 + SLS), PD10 BK—film at initial time (drug + PVP/VA S-630 + SLS), VAD20—film at 1 month (drug + PVP/VA S-630 + SLS), HAS—HPMC AS, HASD—film at initial time (drug + HPMC AS + SLS), HS24—film at 1 month (drug + HPMC AS + SLS), HAD 20 20—film at initial time (drug + HPMC AS + SLS), HS20—film at 1 month (drug + HPMC AS + SLS), PX—Poloxamer 407, PXD10—film at initial time (drug + Poloxamer 407 + SLS), PXD20—film at initial time (drug + Poloxamer 407 + SLS)).

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