A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method

Figure 4

DSC thermogram after 1-day and 1-month stability (a) AT: HPMC HP55 (1 : 1), (b) AT: HPMC HP55 (2 : 3), (c) AT: PEG4000 (1 : 1), (d) AT: PEG4000 (2 : 3), (e) AT: SOLUPLUS (1 : 1), (f) AT: SOLUPLUS (2 : 3) (sample codes in thermogram: AMX—amoxicillin trihydrate, SL—SLS (sodium lauryl sulfate), HH 5—HPMC HP 55, HD24—film at initial time (drug + HPMC HP 55 + SLS), HD264—film at 1 month (drug + HPMC HP 55 + SLS), HH 5—HPMC HP 55, HD20—film at 1 month (drug + HPMC HP 55 + SLS), PGH—PEG 4000, PG24—film at initial time (drug + PEG 4000 + SLS), PG20—film at initial time (drug + PEG 4000 + SLS) SP—Soluplus, SD10—film at initial time (drug + Soluplus + SLS), SPD24—film at 1 month (drug + Soluplus + SLS), SD20—film at initial time (drug + Soluplus + SLS), SPD20—film at 1 month (drug + Soluplus + SLS)).

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