Association between Neutrophil Levels on Admission and All-Cause Mortality in Geriatric Patients with Hip Fractures: A Prospective Cohort Study of 2,589 Patients
Table 1
The demographic and clinical characteristics (N = 2589).
Neutrophil tertiles ()
Low group (0.92–5.43)
Middle group (5.44–7.71)
High group (7.72–24.86)
P value
P value∗
N
871
848
870
Age (years)
79.43 ± 6.86
79.72 ± 6.88
79.61 ± 6.65
0.675
0.511
Sex
0.727
—
Male
278 (31.92%)
286 (33.73%)
285 (32.76%)
Female
593 (68.08%)
562 (66.27%)
585 (67.24%)
Neutrophil ()
4.22 ± 0.89
6.54 ± 0.65
10.00 ± 2.26
<0.001
<0.001
Occupation
0.611
—
Retirement
485 (55.68%)
488 (57.55%)
516 (59.31%)
Farmer
222 (25.49%)
209 (24.65%)
198 (22.76%)
Other
164 (18.83%)
151 (17.81%)
156 (17.93%)
History of allergy
39 (4.48%)
31 (3.66%)
31 (3.56%)
0.556
—
Injury mechanism
0.27
—
Falling
840 (96.44%)
818 (96.46%)
843 (96.90%)
Accident
20 (2.30%)
26 (3.07%)
22 (2.53%)
Other
11 (1.26%)
4 (0.47%)
5 (0.57%)
Fracture classification
<0.001
—
Intertrochanteric fracture
585 (67.16%)
627 (73.94%)
675 (77.59%)
Femoral neck fracture
263 (30.20%)
203 (23.94%)
169 (19.43%)
Subtrochanteric fracture
23 (2.64%)
18 (2.12%)
26 (2.99%)
Hypertension
377 (43.28%)
425 (50.12%)
456 (52.41%)
<0.001
—
Diabetes
160 (18.37%)
171 (20.17%)
185 (21.26%)
0.312
—
CHD
445 (51.09%)
441 (52.00%)
491 (56.44%)
0.058
—
Arrhythmia
301 (34.56%)
273 (32.19%)
298 (34.25%)
0.531
—
Hemorrhagic stroke
26 (2.99%)
15 (1.77%)
16 (1.84%)
0.153
—
Ischemic stroke
241 (27.67%)
236 (27.83%)
278 (31.95%)
0.084
—
Cancer
36 (4.13%)
20 (2.36%)
19 (2.18%)
0.028
—
Multiple injuries
58 (6.66%)
58 (6.84%)
65 (7.47%)
0.784
—
Dementia
28 (3.21%)
43 (5.07%)
32 (3.68%)
0.123
—
COPD
60 (6.89%)
47 (5.54%)
61 (7.01%)
0.392
—
Hepatitis
41 (4.71%)
20 (2.36%)
20 (2.30%)
0.005
—
Gastritis
20 (2.30%)
15 (1.77%)
11 (1.26%)
0.265
—
aCCI
4.18 ± 1.06
4.21 ± 1.08
4.27 ± 1.10
0.234
0.169
Treatment strategy
<0.001
—
Conservation
61 (7.00%)
74 (8.73%)
90 (10.34%)
ORIF
542 (62.23%)
583 (68.75%)
618 (71.03%)
HA
250 (28.70%)
182 (21.46%)
154 (17.70%)
THA
18 (2.07%)
9 (1.06%)
8 (0.92%)
Time to admission (h)
140.31 ± 378.47
57.58 ± 144.38
44.13 ± 119.43
<0.001
<0.001
Time to operation (d)
4.11 ± 2.46
4.46 ± 2.73
4.35 ± 2.53
0.024
0.019
Operation time (mins)
91.16 ± 34.44
92.97 ± 38.64
98.21 ± 38.05
<0.001
<0.001
Blood loss (mL)
248.18 ± 164.28
254.20 ± 181.75
234.18 ± 138.97
0.05
0.099
Transfusion (U)
1.15 ± 1.25
1.21 ± 1.32
1.11 ± 1.25
0.327
0.413
Infusion (mL)
1545.87 ± 376.84
1540.57 ± 387.42
1593.84 ± 398.42
0.013
0.024
Follow-up (m)
39.03 ± 19.17
39.71 ± 19.93
38.12 ± 19.88
0.242
0.225
Mortality
273 (31.34%)
284 (33.49%)
318 (36.55%)
0.07
—
Mean + SD/N (%). P value∗: for continuous variables, we used the Kruskal–Wallis rank sum test and Fisher’s exact probability test for count variables with a theoretical number <10.
