The Impact of Pharmacist-Managed Service on Warfarin Therapy in Patients after Mechanical Valve Replacement

Table 3

Multivariate logistic regression models for factors associated with the outcomes of interests.

Factors	Therapeutic INR at discharge		Supratherapeutic INR during hospital stay
	OR (95% CI)	value	OR (95% CI)	value
PMWT	3.33 (1.03–10.76)	0.045	0.19 (0.04–0.84)	0.029
Age (years)	0.99 (0.95–1.03)	0.726	0.99 (0.94–1.04)	0.652
Sex	0.53 (0.15–1.92)	0.333	1.87 (0.37–9.54)	0.452
LVEF (%)	0.98 (0.94–1.02)	0.289	1.02 (0.97–1.08)	0.439
Scr (mg/dL)	0.49 (0.11–2.14)	0.343	5.83 (0.32–107.78)	0.236
ALT (U/L)	0.98 (0.95–1.00)	0.083	0.98 (0.94–1.02)	0.314
Any DDI	1.27 (0.43–3.74)	0.667	0.81 (0.22–2.91)	0.744

Statistically significant (). ALT, alanine aminotransferase; DDIs, drug-drug interactions; CI, confidence interval; INR, international normalized ratio; LVEF, left ventricular ejection fraction; OR, odds ratio; PMWT, pharmacist-managed warfarin therapy; Scr, serum creatinine.