Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Table 1

Basic data of patients in 9 papers.

Included literature

Country

Study type

Number of patients

Age (average)

Sex ratio (male/female)

BMI (average)

Arthritis grade I/II/III/IV

Interventions

Follow-up time

Outcome indicators

T

C

T

C

T

C

T/C

T

C

Bostos et al. [18]

Brazil

RCT

14

16

60.8

55.7

9/5

6/10

28.9/30.6

1/3/6/4

1/7/5/3

PRP-MSC

1, 12

(2) (3)

Cheng[3]

China

RCT

20

20

54.6

52.9

8/15

9/11

—

8/8/4/0

7/8/5/0

PRP-MSC

1, 3, 6

(1) (4)

Dulic et al. [12]

Serbia

RCT

111

34

56.9

58.8

57/54

15/19

28.6/28.47

0/49/46/16

0/12/12/10

PRP-MSC

1, 3, 6, 9, 12

(2) (3) (4) (5)

Ha et al. [11]

China

RCT

45

44

56.8

55.6

15/30

14/30

25.5/25.4

—

—

PRP-MSC

1, 3, 6, 12

(1)

Koh et al. [19]

USA

RCT

21

23

54.2

52.3

5/16

6/17

25.7/24.7

—

—

PRP-MSC

1, 12

(1) (2) (3)

Lamo-Espinosa et al. [20]

Spain

RCT

24

26

56

54.6

17/7

16/10

27/25.3

5/5/2/12

0/8/5/13

PRP-BM/MSC

1, 3, 6, 12

(1) (4)

Schweich-Adami et al. [21]

Brazil

RCT

6

6

52.66

48

3/3

4/2

31.08/27.3

0/2/3/1

0/2/4/0

PRP-AD/MSC

1, 6

(1) (4)

Ruane et al. [5]

USA

RCT

17

15

58.06

58.60

9/8

10/5

29.19/29.21

5/6/6/0

2/8/5/0

PRP-MSC

1, 3, 6, 12

(2) (3)

Venosa et al. [22]

Italy

RCT

19

19

55.8

56.4

9/10

12/7

25.8/26.2

0/0/0/19

0/0/0/19

PRP-AD/MSC

1, 3, 6, 12

(1) (2) (3) (5)

Note: RCT, randomized controlled trial; , experimental group; C, control group. Outcome measures: (1) visual analogue scale (VAS) score, (2) knee injury and osteoarthritis outcome score (KOOS), (3) total KOOS score, (4) total Western Ontario and McMaster Universities (WOMAC) score; and (5) International Knee Documentation Committee (IKDC) score.