Clinical Outcomes Based on the Attainment of Low-Density Lipoprotein Cholesterol Targets in Patients with Acute Coronary Syndrome in Real-World Practice
Table 2
Baseline characteristics and clinical outcomes in the patients with decreasing LDL-C level ≥50% and with or without LDL-C level <70 mg/dL.
<70 mg/dL
≥70 mg/dL
value
Number
2741
626
General demographics
Age (years)
62 (12.8)
58 (11.9)
<0.001
Male sex (%)
2129 (77.67)
482 (77.00)
0.715
BMI (kg/m2)
25.78 (3.92)
25.74 (3.73)
0.845
Comorbidities
Smoking (%)
550 (20.07)
158 (25.24)
0.004
Hypertension (%)
1670 (60.93)
326 (52.08)
<0.001
Diabetes mellitus (%)
1276 (46.55)
216 (34.50)
<0.001
COPD (%)
77 (2.81)
11 (1.76)
0.137
ESRD (%)
200 (7.30)
22 (3.51)
<0.001
Liver cirrhosis (%)
18 (0.66)
4 (0.64)
0.960
Prior GI bleeding (%)
134 (4.89)
23 (3.67)
0.193
Prior stroke (%)
132 (4.82)
19 (3.04)
0.052
Lipid lower agents (%)
High-intensity statin (%)
2162 (78.88)
508 (81.15)
0.205
Ezetimibe (%)
286 (10.43)
86 (13.74)
0.017
LDL-C level (mg/dl)
Baseline level (mg/dL)
130.00 ± 31.27
187.90 ± 35.78
<0.001
The lowest level (mg/dL)
49.61 ± 12.18
81.86 ± 12.06
<0.001
Decreasing percentage (%)
61.21 ± 7.88
55.86 ± 4.82
<0.001
Clinical outcomes
1-year
CV mortality (%)
53 (1.93)
7 (1.12)
0.164
All-cause mortality (%)
131 (4.78)
16 (2.56)
0.014
3-year
CV mortality (%)
130 (4.74)
15 (2.40)
0.009
All-cause mortality (%)
348 (12.70)
53 (8.47)
0.003
The data are expressed as the mean (standard deviation) or as a number (percentage). Abbreviation: LDL-C, low density lipoprotein-cholesterol; BMI, body mass index; COPD, chronic obstructive pulmonary disease; ESRD, end stage renal disease; GI, gastrointestinal; CV, cardiovascular.
