Human Umbilical Cord Wharton Jelly Cells Treatment Prevents Osteoporosis Induced by D-Galactose

Figure 1

HUCWJCs partially rescue the osteoporosis phenotype induced by oxidative stress. (a) ELISA result of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum. (b) ELISA result of alkaline phosphatase (ALP) in serum. (c) Representative μCT scans of the distal femur showing the 3D reconstructed trabecular bones of mice at 8 months of age and quantitative analysis of the trabecular bone mass density (Tb.BMD), trabecular bone surface area/tissue volume (Tb.BS/BV), percentage of bone volume (BV/TV), trabecular thickness (Tb. Th), trabecular number (Tb. N), and trabecular spacing (Tb. Sp) (n = 3). (d) Quantification of the μCT result. (e) Hematoxylin & eosin staining of 8-month-old mice showed the trabecular bone at the distal femur and quantification of trabecular bone tissue area/total area. Scale bar, 200uM. All data is reported as the mean ± SD. Statistical significance was determined by one-way ANOVA. _,, ; ns = not statistically significant.

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