Review Article
Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis
Table 3
Results of subgroup analyses for the association between sarcopenia and acute mortality of patients with sepsis.
| | Study characteristics | Datasets number | RR (95% CI) | I2 | for the subgroup effect | for subgroup difference |
| | Design | | Prospective | 1 | 2.14 (1.60, 2.87) | NA | 0.006 | | | Retrospective | 8 | 7.67 (1.80, 32.68) | 37% | <0.001 | 0.08 | | Country | | Asian | 7 | 1.85 (1.43, 2.40) | 25% | <0.001 | | | Non-Asian | 2 | 3.83 (1.92, 7.67) | 16% | <0.001 | 0.07 | | Clinical settings | | ED | 2 | 2.92 (1.69, 5.03) | 0% | <0.001 | | | ICU | 7 | 2.01 (1.44, 2.81) | 51% | <0.001 | 0.25 | | Diagnosis of sepsis | | Sepsis-1 or sepsis-2 | 2 | 2.94 (1.73, 5.01) | 0% | <0.001 | | | Sepsis-3 | 7 | 2.01 (1.45, 2.79) | 49% | <0.001 | 0.23 | | Mean age | | <70 years | 5 | 2.54 (1.43, 4.53) | 66% | 0.002 | | | 70 years or above | 4 | 1.95 (1.46, 2.60) | 0% | <0.001 | 0.42 | | Proportion of men | | <65% | 4 | 3.07 (1.94, 4.86) | 0% | <0.001 | | | 65% or above | 5 | 1.84 (1.32, 2.55) | 50% | <0.001 | 0.07 | | Diagnosis of sarcopenia | | SMI | 6 | 2.11 (1.41, 3.16) | 51% | <0.001 | | | SMA | 2 | 1.96 (1.17, 3.28) | 36% | 0.01 | | | MAMC | 1 | 3.20 (1.73, 5.93) | NA | <0.001 | 0.44 | | Duration | | In-hospital mortality | 6 | 2.01 (1.39, 2.90) | 58% | <0.001 | | | 1-month mortality | 3 | 2.77 (1.71, 4.50) | 0% | <0.001 | 0.30 | | Quality score | | NOS = 7 | 3 | 2.38 (1.42, 3.98) | 44% | = 0.001 | | | NOS = 8 | 4 | 2.81 (1.88, 4.19) | 0% | <0.001 | | | NOS = 9 | 2 | 1.42 (1.05, 1.91) | 0% | 0.02 | 0.08 |
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RR, risk ratio; CI, confidence interval; NA, not applicable; ED, emergency department; ICU, intensive care unit; SMI, skeletal muscle index; SMA, skeletal muscle area; MAMC, midarm muscle circumference; NOS, Newcastle–Ottawa Scale.
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