Review Article
Influence of Statins on the Survival Outcomes of Patients with Diffuse Large B Cell Lymphoma: A Systematic Review and Meta-Analysis
Table 3
Subgroup analyses for the outcomes of BW and BMI.
| | Characteristics | OS | PFS | | No. of studies | HR (95% CI) | I2 | P1 | P2 | No. of studies | HR (95% CI) | I2 | P1 | P2 |
| | Study design | | Prospective | 2 | 0.88 (0.69, 1.12) | 0% | 0.31 | | 1 | 0.85 (0.43, 1.68) | — | 0.64 | | | Retrospective | 6 | 0.88 (0.62, 1.25) | 70% | 0.47 | 1.00 | 5 | 0.92 (0.69, 1.23) | 37% | 0.54 | 0.84 |
| | Country | | Asian | 3 | 1.19 (0.91, 1.56) | 2% | 0.19 | | 3 | 1.13 (0.89, 1.44) | 0% | 0.33 | | | Western | 5 | 0.73 (0.66, 0.81) | 0% | <0.001 | <0.001 | 3 | 0.72 (0.53, 0.96) | 0% | 0.03 | 0.02 |
| | Mean age | | ≤60 years | 2 | 1.56 (0.75, 3.26) | 0% | 0.23 | | 2 | 0.85 (0.37, 1.95) | 45% | 0.71 | | | >60 years | 4 | 0.87 (0.66, 1.15) | 75% | 0.33 | 0.14 | 3 | 0.91 (0.62, 1.33) | 56% | 0.62 | 0.89 |
| | Quality scores | | 6–7 | 3 | 0.86 (0.63, 1.18) | 72% | 0.35 | | 1 | 1.15 (0.64, 2.06) | — | 0.64 | | | 8–9 | 5 | 0.90 (0.64, 1.26) | 26% | 0.54 | 0.86 | 5 | 0.87 (0.66, 1.16) | 33% | 0.36 | 0.41 |
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OS, overall survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; P1, p values for subgroup effect; P2, p values for subgroup difference.
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