Research Article

Impact of BMI on Long-Term Outcomes in Patients with ST-Segment Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention

Table 1

Baseline profile and treatment characteristics of younger and older STEMI patients.

≤65 y value>65 y value
BMIBMI
NormalOverweightObesityNormalOverweightObesity
<24 (n = 168)24–28 (n = 596)>28 (n = 228)<24 (n = 50)24–28 (n = 198)>28 (n = 189)

Age, years52 ± 952 ± 851 ± 80.84771 ± 472 ± 472 ± 40.444
Male, n (%)146 (86.9)492 (82.6)198 (86.8)0.18734 (68.0)170 (85.9)147 (77.8)0.008
Hypertension, n (%)84 (50.0)304 (51.0)150 (65.8)<0.00128 (56.0)122 (61.6)108 (57.1)0.314
Diabetes mellitus, n (%)44 (26.2)124 (20.8)78 (34.2)<0.0018 (16.0)58 (29.3)48 (25.4)0.099
Smoking status, n (%)0.042<0.01
 Current smoking96 (57.1)352 (59.1)144 (63.2)22 (44.0)130 (65.7)129 (68.3)
 Ex-smoking4 (2.4)28 (4.7)12 (5.3)4 (8.0)4 (2.0)12 (6.3)
 Never68 (40.5)216 (36.2)72 (31.6)24 (48.0)64 (32.3)48 (25.4)
Previous stroke, n (%)6 (3.6)28 (4.7)6 (2.6)0.3818 (14.3)20 (10.0)21 (11.1)0.063
Previous PCI, n (%)6 (3.6)36 (6.0)6 (2.6)0.0882 (3.6)0 (0)0 (0)0.001
Medication before AMI, n (%)
 Aspirin10 (6.0)56 (9.4)30 (13.2)0.0534 (8.0)16 (8.1)6 (3.2)0.207
 ACEIs/ARBs18 (10.7)68 (11.4)36 (15.8)0.1828 (16.0)36 (18.2)24 (12.7)0.627
 Beta-blocker10 (6.0)56 (9.4)36 (15.8)0.00312 (24.0)16 (8.1)6 (3.2)<0.01
 Statins4 (2.4)28 (4.7)12 (5.3)0.3434 (8.0)4 (2.0)0 (0)0.003
Time-to-hospital admission, h13 ± 1417 ± 2619 ± 260.05611 ± 1420 ± 2518 ± 270.330
Physical findings on admission
 SBP, mmHg113 ± 26121 ± 17121 ± 22<0.01114 ± 27118 ± 18121 ± 180.551
 DBP, mmHg72 ± 1476 ± 1276 ± 150.00575 ± 1173 ± 1274 ± 100.553
 HR, beats/min75 ± 1676 ± 1178 ± 190.22376 ± 1279 ± 1878 ± 160.377
Glucose, mmol/L5.4 ± 1.97.7 ± 2.95.4 ± 2.70.5214.7 ± 1.95.1 ± 2.35.4 ± 1.60.291
hs-CRP, mmol/L8.5 (0.7–42.6)9.6 (0.2–42.5)8.8 (0.2–41.2)0.5178.1 (0.6–34.3)11.7 (0.9–40.9)10.9 (0.22–43.3)0.743
BNP, mmol/L68.8 (2.4–1886)121.7 (3.7–3217)99.5 (4.9–2381)0.4155.8 (0.1–135)264 (39.6–3321)130 (2.7–2100)0.258
LDL-C, mmol/L2.8 ± 0.82.9 ± 0.83.0 ± 0.60.3112.7 ± 0.62.9 ± 0.93.1 ± 0.70.048
TG, mmol/L1.8 ± 1.02.0 ± 1.32.4 ± 1.60.0021.9 ± 1.31.9 ± 1.52.1 ± 1.10.308
Uric acid, umol300 ± 106308 ± 95307 ± 1180.705318 ± 115296 ± 80352 ± 1100.005
Peak CK-MB, mU/ml391 ± 995210 ± 200209 ± 2230.004218 ± 188237 ± 239298 ± 2930.141
Killip classes ≥2132 (78.6)440 (73.8)144 (63.2)0.00138 (76.0)134 (67.7)135 (71.4)0.390
IRA, n (%)0.0120.308
 LM4 (2.4)4 (0.7)0 (0)0 (0)0 (0)0 (0)
 LAD86 (51.2)296 (49.7)138 (60.5)30 (60.0)104 (52.5)102 (54)
 LCX36 (21.4)80 (13.4)18 (7.9)6 (12.0)24 (12.1)42 (22.2)
 RCA42 (25.0)216 (36.2)72 (31.6)14 (28.0)68 (34.3)45 (23.8)
Triple disease, n (%)38 (22.6)152 (25.5)66 (28.9)0.35118 (36.0)52 (26.3)30 (15.9)0.048
Initial TIMI flow 0, n (%)90 (53.6)356 (59.7)138 (60.5)0.30336 (72.0)146 (73.7)117 (61.9)0.036
Stent length, mm24 ± 624 ± 625 ± 70.45224 ± 624 ± 725 ± 60.804
Stent diameter, mm2.7 ± 0.92.8 ± 0.83 ± 0.70.0152.9 ± 0.72.9 ± 0.62.9 ± 0.50.862
Echocardiography
 LVEF, %55 ± 1154 ± 1054 ± 90.89853 ± 1256 ± 953 ± 70.085
 LVESD, mm33 ± 434 ± 735 ± 70.09834 ± 431 ± 639 ± 90.004
 LVEDD, mm50 ± 2148 ± 749 ± 60.34348 ± 348 ± 549 ± 40.357
 LVA, n (%)6 (3.6)20 (3.4)12 (5.3)0.4354 (8.0)12 (6.1)18 (9.5)0.235
Bleedings, n (%)22 (13.1)38 (6.4)12 (5.3)0.5148 (16.0)8 (4.0)2 (1.1)0.018
 TIMI major bleeding000000
 TIMI minor bleeding6 (3.6)12 (2.0)3 (1.3)1 (2.0)00
 TIMI minimal bleeding16 (9.5)26 (4.4)9 (3.9)7 (14.0)8 (4.0)2 (1.1)

Values are n (%) or means ± SD. BMI, body mass index; PCI, percutaneous coronary intervention; AMI, acute myocardial infarction; ACEIs, angiotensin-converting enzyme inhibitors; ARBs, angiotensin receptor blockers; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; hs-CRP, high-sensitivity C-reactive protein; BNP, B-type natriuretic peptide; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride; CK, creatine kinase; IRA, infarct-related artery; LM, left main; LAD, left anterior descending artery; RCA, right coronary artery; LCX, left circumflex artery; TIMI, Thrombolysis in Myocardial Infarction grade; LVEF, left ventricular ejection fraction; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic diameter; LAV, left ventricular aneurysm.