Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Table 1

Comparison of serum GSH, CAT, SOD, and 8OH-dG levels between groups.

Groups	GSH (mmol/L)	CAT (U/L)	SOD (IU/Ml)	8-OHdG (pg/ml)
Control	240.93 ± 27.49^b	18.39 ± 0.40^a,b	0.63 ± 0.03^a	1.24 ± 0.093^c
Cisplatin	161.48 ± 17.72^c	15.91 ± 1.43^b	0.15 ± 0.08^e	1.86 ± 0.28^a
Cis + gal	244.59 ± 9.58^b	17.09 ± 4.68^a,b	0.30 ± 0.02^c,d,e	1.31 ± 0.13^b,c
Cis + sly	214.96 ± 44.56^b	15.18 ± 1.98^b	0.28 ± 0.10^d,e	1.75 ± 0.29^a,b
Cis + sly + gal	237.21 ± 23.40^b	22.32 ± 2.56^a	0.27 ± 0.13^d,e	1.78 ± 0.31^a,b
Silymarin	287.32 ± 27.93^a	20.93 ± 2.92^a,b	0.58 ± 0.28^a,b	1.57 ± 0.40^a,b,cb
Gallic acid	290.21 ± 18.82^a	17.42 ± 5.25^a,b	0.52 ± 0.10^a,b,c	1.43 ± 0.19^a,b,c
Gal + sly	252.96 ± 31.66^a,b	22.73 ± 0.83^a	0.39 ± 0.10^b,c,d	1.29 ± 0.46^b,c

a, b, and c: the statistical difference between groups with different letters in the same column is significant (). Control: control group; cisplatin: cisplatin group; cis + gal: cisplatin + gallic acid; cis + sly: cisplatin + silymarin; cis + sly + gal: cisplatin + gallic acid + silymarin; silymarin: silymarin group; gallic acid: gallic acid group; gal + sly: gallic acid + silymarin.