Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Table 2

Comparison of GSH, CAT, SOD, MDA, and 8OH-dG levels in liver tissue between groups.

Groups	GSH (mmol/L)	CAT (U/L)	SOD (IU/Ml)	MDA (mmol/L)	8-OHdG (pg/ml)
Control	137.94 ± 21.17^b,c	27.04 ± 2.64^a	1.69 ± 0.43^a,b	0,70 ± 0.22^d	2.27 ± 0.33^c
Cisplatin	109.71 ± 10.56^d	18.83 ± 4.00^b	1.13 ± 0.37^b	2.07 ± 0,21^a	3.91 ± 0.65^a
Cis + gal	151.22 ± 5.72^a,b	25.82 ± 1.16^a	1.90 ± 0.30^a	1,01 ± 0,13^c	2.68 ± 0.45^b,c
Cis + sly	164.59 ± 5.51^a	24.22 ± 3.09^a,b	1.90 ± 0.47^a	1,45 ± 0,41^b	2.56 ± 0.11^b,c
Cis + sly + gal	132.41 ± 18.51^b,c,d	22.38 ± 3.34^a,b	2.33 ± 0.73^a	1,12 ± 0,07^c	2.63 ± 0.72^b,c
Silymarin	144.76 ± 17.91^a,b,c	22.43 ± 3.81^a,b	1.96 ± 0.36^a	0,99 ± 0,26^c	2.99 ± 0.22^b,c
Gallic acid	124.92 ± 16.74^c,d	26.41 ± 2.46^a	1.60 ± 0.32^a,b	1,24 ± 0,09^b,c	2.73 ± 0.56^b,c
Gal + sly	136.30 ± 15.06^b,c	23.53 ± 5.80^a,b	1.66 ± 0.58^a,b	1,44 ± 0,19^b	2.68 ± 0.45^b

a, b, c, d, and e: the statistical difference between groups with different letters in the same column is significant (). Control: control group; cisplatin: cisplatin group; cis + gal: cisplatin + gallic acid; cis + sly: cisplatin + silymarin; cis + sly + gal: cisplatin + gallic acid + silymarin; silymarin: silymarin group; gallic acid: gallic acid group; gal + sly: gallic acid + silymarin.