Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Table 3

Comparison of GSH, CAT, SOD, MDA, and 8OH-dG levels in kidney tissue between groups.

Groups	GSH (mmol/L)	CAT (U/L)	SOD (IU/Ml)	MDA (mmol/L)	8-OHdG (pg/ml)
Control	135.96 ± 30.46^a	30.60 ± 3.38^a	2.44 ± 0.27^a,b	1,36 ± 0,21^b,c,d	2.19 ± 0.38^e
Cisplatin	106.10 ± 27.46^a	20.67 ± 3.45^c	1.73 ± 0.33^c	2.30 ± 0,21^a	4.66 ± 0.47^a
Cis + gal	167.53 ± 28.96^a	24.23 ± 2.45^b,c	2.38 ± 0.38^a,b	1,13 ± 0,07^d,e	3.05 ± 0.11^b,c,d
Cis + sly	162.82 ± 37.01^a	25.54 ± 5.80^b,c	2.30 ± 0.47^a,b	1,57 ± 0,01^b	3.78 ± 0.46^b
Cis + sly + gal	128.87 ± 24.80^a	22.27 ± 1.50^b,c	2.87 ± 0,41^a	1,10 ± 0,08^e	3.30 ± 0.86^b,c,d
Silymarin	142.57 ± 25.14^a	23.65 ± 1.26^b,c	2.40 ± 0.42^a,b	1,25 ± 0,17^c,d,e	3.75 ± 0.31^b,c
Gallic acid	112.04 ± 100.11^a	26.19 ± 1.76^a,b	2.43 ± 0.34^a,b	1,45 ± 0,77^b,c	2.92 ± 0.25^d,e
Gal + sly	136.09 ± 13.92^a	23.16 ± 2.16^b,c	2.23 ± 0.18^b,c	1,13 ± 0,27^d,e	2.95 ± 0.61^c,d,e

a, b, and c: the statistical difference between groups with different letters in the same column is significant (). Control: control group; cisplatin: cisplatin group; cis + gal: cisplatin + gallic acid; cis + sly: cisplatin + silymarin; cis + sly + gal: cisplatin + gallic acid + silymarin; silymarin: silymarin group; gallic acid: gallic acid group; gal + sly: gallic acid + silymarin.