Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Table 4

Intergroup hemogram results.

Groups	WBC	RBC	HGB	HCT	PLT
Control	4.13 ± 1.33^c	6.89 ± 0.49^d	13.72 ± 1.13^c	48.40 ± 4.40^a	1062.25 ± 133.^a
Cisplatin	7.56 ± 3.70^b,c	8.26 ± 0.67^a,b,c	16.56 ± 1.06^a	50.46 ± 2.37^a	686.33 ± 235.92^b
Cis + gal	6.58 ± 2.15^b,c	8.44 ± 0.85^a,b	16.80 ± 1.41^a	53.33 ± 3.26^a	949.33 ± 134.79^a,b
Cis + sly	10.65 ± 1.18^a,b	8.42 ± 0.74^a,b	16.35 ± 1.48^a,b	53.90 ± 6.08^a	1030.50 ± 219.91^ab
Cis + sly + gal	14.36 ± 3.55^a	8.71 ± 0.75^a	16.60 ± 1.44^a	55.26 ± 3.70^a	806.00 ± 271.06^a,b
Silymarin	8.11^b,c	7.29^c,d	14.40^b,c	50.50^a	893.00^a,b
Gallic acid	7.68 ± 1.46^b,c	7.52 ± 0.21^b,c,d	14.93 ± 0.97^a,b,c	52.46 ± 3.91^a	816.00 ± 176.90^a,b
Gal + sly	8.02 ± 1.58^b,c	7.39 ± 0.23^b,c,d	15.63 ± 0.32^a,b,c	52.93 ± 1.76^a	789.33 ± 89.114^a,b

a, b, and c: the statistical difference between groups with different letters in the same column is significant (). Control: control group; cisplatin: cisplatin group; cis + gal: cisplatin + gallic acid; cis + sly: cisplatin + silymarin; cis + sly + gal: cisplatin + gallic acid + silymarin; silymarin: silymarin group; gallic acid: gallic acid group; gal + sly: gallic acid + silymarin.