Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Table 5

Intergroup biochemistry results.

Groups	AST (IU/L)	ALT (IU/L)	Urea (mg/dl)	Creati̇ni̇ne (mg/dl)	Albumin (g/dl)	Globulin (g/dl)	Total protein (g/dl)
Control	108.20 ± 12.47^a,b	32.00 ± 3.05^a	53.80 ± 6.97^c,d	0.48 ± 0.04^b	28.40 ± 2.7^a,b	28.60 ± 3.05^b	57.00 ± 5.29^a
Cisplatin	124.67 ± 6.65^a	35.67 ± 3.78^a	74.67 ± 6.65^a	2.41 ± 0.37^a	26.33 ± 1.15^a,b	29.00 ± 3.60^b	55.33 ± 4.50^a
Cis + gal	94.00 ± 24.52^b	23.60 ± 7.60^a	57.50 ± 3.69^c,d	0.59 ± 0.08^b	25.00 ± 1.58^b	31.20 ± 6.83^a,b	56.20 ± 6.09^a
Cis + sly	96.40 ± 10.47^a,b	30.60 ± 8.38^a	62.20 ± 9.52^b,c	0.62 ± 0.22^b	26.80 ± 1.78^a,b	29.60 ± 1.34^a,b	56.40 ± 3.05^a
Cis + sly + gal	110.80 ± 38.88^a,b	35.80 ± 12.91^a	70.80 ± 13.44^a,b	0.72 ± 0.36^b	26.00 ± 3.60^a,b	34.60 ± 4.03^a	60.60 ± 4.98^a
Silymarin	89.83 ± 10.96^b	33.17 ± 6.96^a	40.83 ± 5.63^e	0.44 ± 0.02^b	29.17 ± 0.75^a	29.67 ± 1.03^a,b	58.83 ± 0.98^a
Gallic acid	95.00 ± 9.21^b	32.00 ± 5.29^a	48.50 ± 8.42^d,e	0.45 ± 0.04^b	28.50 ± 0.57^a,b	29.75 ± 0.50^a,b	58.25 ± 0.95^a
Gal + sly	100.50 ± 5.91^a,b	29.75 ± 9.77^a	56.67 ± 2.51^c,d	0.49 ± 0.05^b	29.25 ± 3.59^a	32.00 ± 1.15^a,b	61.25 ± 4.34^a

a, b, and c: the statistical difference between groups with different letters in the same column is significant (). Control: control group; cisplatin: cisplatin group; cis + gal: cisplatin + gallic acid; cis + sly: cisplatin + silymarin; cis + sly + gal: cisplatin + gallic acid + silymarin; silymarin: silymarin group; gallic acid: gallic acid group; gal + sly: gallic acid + silymarin.