Time Trends and Treatment Pathways in Prescribing Individual Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation: An Observational Study of More than Three Million Patients from Europe and the United States

Figure 3

Two-year OAC treatment sequences (irrespective of gaps in treatment) in patients with AF by database and study year (patients still available for observation at 2 years after their index prescription). Note: the inner circle of each sunburst plot shows the percentage of patients prescribed each OAC type (first OAC prescription) in that year, coloured segments in the next outer circle show the second OAC prescribed (if any) at any time during the two-year follow-up period (i.e., the first OAC switch), and coloured segments in the second outer circle (if any) show the third OAC prescribed (if any) at any time during the two-year follow-up period (either a switch back to the original OAC prescribed or a switch to another different OAC. Also, very few patients were available for analysis in the US Longitudinal Prescription Diagnosis database and the French Disease Analyzer database in 2010. Hence, results are not shown for these databases in this year. Each cell in the sunburst plot represents 2%.