Adherence to Medication among Parkinson’s Disease Patients Using the Adherence to Refills and Medications Scale

Table 2

Variables associated with lower adherence on medication and logistic regression model examining predictors of lower adherence.

Variables	B	OR (95% CI for OR)	value	B	OR (95% CI for OR)	value
Sex	−0.158	0.854 (0.364–2.003)	0.717
Actual age	−0.049	0.952 (0.895–1.012)	0.117
Education	−0.421	0.657 (0.314–1.373)	0.264
Age at onset	−0.064	0.938 (0.887–0.992)	0.026			0.195
Disease duration (years)	0.096	1.101 (0.981–1.235)	0.101
Form of disease	0.327	1.387 (0.582–3.302)	0.460
Number of levodopa doses per day	0.319	1.375 (0.808–2.339)	0.240
Number of drugs per day^∗	0.267	1.306 (0.938–1.818)	0.113
Levodopa average daily dose (mg/day)	0.002	1.002 (1.000–1.005)	0.031			0.064
LEDD (mg/day)	0.002	1.002 (1.000–1.003)	0.011			0.107
Motor fluctuations	1.014	2.756 (1.142–6.647)	0.024			0.236
Presence of dyskinesia	0.823	2.276 (0.929–5.581)	0.072
Presence of hallucinations	1.203	3.331 (1.156–9.596)	0.026			0.116
UPDRS total score	0.025	1.026 (1.001–1.052)	0.044			0.493
HY stage	0.701	2.016 (0.893–4.553)	0.091
S&E scale	−0.038	0.962 (0.928–0.998)	0.036			0.337
HDRS>7	1.133	3.106 (1.298–7.432)	0.011	1.238	3.449 (1.425-8,350)	0.006
HARS>14	0.212	1.236 (0.411–3.719)	0.706
NMSQuest	0.093	1.097 (1.012–1.189)	0.025			0.459

^∗indicates the number of drugs per day (number of antiparkinsonian drugs, benzodiazepines, antipsychotics, and antidepressants per day). Patient characteristics that differed significantly between groups () are shown in boldface. B, B coefficient; OR, odd ratio; CI, confidence interval; LEDD, levodopa equivalent daily dose; UPDRS, Unified Parkinson’s Disease Rating Score; HY, Hoehn and Yahr stage; S&E, Schwab–England scale; HDRS, Hamilton Depression Rating Scale; HARS, Hamilton Anxiety Rating Scale; NMSQuest, Non-Motor Symptom Questionnaire.