Biomarkers for Predicting the Occurrence and Progression of Atrial Fibrillation: Soluble Suppression of Tumorigenicity 2 Protein and Tissue Inhibitor of Matrix Metalloproteinase-1
Table 3
Univariate ordinal logistic regression analysis of the factors with sinus rhythm and paroxysmal, persistent AF.
Variable
Coef
SE
95% CI
value
Age (years)
0.055
0.008
0.039–0.071
<0.001
Male
0.827
0.204
0.427–1.226
<0.001
BMI
0.059
0.023
0.013–0.105
0.011
HTN n (%)
0.968
0.201
0.575–1.361
<0.001
CHA2DS2-VASc
0.214
0.075
0.068–0.360
0.004
HAS-BLED
0.502
0.116
0.274–0.731
<0.001
LAd (mm)
0.160
0.021
0.119–0.201
<0.001
LVEF (%)
−0.054
0.016
−0.085 to −0.023
0.001
LVESD (mm)
0.059
0.021
0.018–0.100
0.005
PLT (1012/l)
−0.007
0.002
−0.011 to −0.004
<0.001
Hb (g/l)
0.019
0.006
0.006–0.031
0.003
CREA (umol/l)
0.025
0.006
0.013–0.037
<0.001
HCY (umol/l)
0.029
0.013
0.004–0.053
0.022
TIMP-1 (ng/ml)
0.024
0.003
0.019–0.030
<0.001
sST2 (pg/ml)
0.126
0.015
0.096–0.155
<0.001
BNP (pg/ml)
0.011
0.002
0.008–0.014
<0.001
TP (g/l)
−0.046
0.018
−0.081 to −0.011
0.010
Alb (g/l)
−0.095
0.025
−0.144 to −0.045
<0.001
Tbil (umol/l)
0.082
0.017
0.048–0.115
<0.001
Dbil (umol/l)
0.317
0.055
0.210–0.424
<0.001
Ibil (umol/l)
0.072
0.020
0.034–0.111
<0.001
LDH (U/l)
0.005
0.002
0.001–0.009
0.007
Tcho (mmol/l)
−0.325
0.096
−0.513 to −0.137
0.001
LDL-c (mmol/l)
−0.217
0.096
−0.405 to −0.030
0.023
hs-CRP (mg/l)
0.085
0.027
0.031–0.138
0.002
FDP (ug/ml)
0.199
0.094
0.014–0.383
0.035
HCT (%)
0.085
0.025
0.035–0.135
0.001
MCV (fl)
0.062
0.022
0.020–0.105
0.004
MCH (pg)
0.112
0.054
0.007–0.218
0.037
RDW-SD (fl)
0.066
0.035
−0.003 to 0.135
0.062
BMI: body mass index; HTN: hypertension; LAd: left atrium diameters; LVEF, left ventricular ejection fraction; LVESD, left ventricular end of systolic dimeter; PLT, platelet count; Hb, hemoglobin; CREA: creatinine; HCY: homocysteine; TIMP-1: tissue inhibitors of metalloproteinase-1; sST2: soluble suppression of tumorigenicity 2; BNP: B-type natriuretic peptide; TP: total protein; Alb: albumin; Glo: globulin; Tbil: total bilirubin; Dbil: direct bilirubin; Ibil: indirect bilirubin; LDH: lactate dehydrogenase; Tcho: total cholesterol; LDL-c: low-density lipoprotein cholesterol; hs-CRP: high-sensitivityC-reactive protein; FDP: fibrinogen degradation products; HCT: hematocrit; MCV: mean red blood cell volume; MCH: mean corpuscular hemoglobin; RDW-SD: red blood cell distribution width-standard deviation.
