Research Article

Association between Gut Microbiota Dysbiosis and the CHA2DS2-VASc Score in Atrial Fibrillation Patients

Table 1

Clinical characteristics of all subjects.

Low CHA2DS2-VASc scoreHigh CHA2DS2-VASc score value (low vs. high)

Number1832
Score0.8 ± 0.83.7 ± 1.2
 Congestive heart failure00
 Male/female12/620/121.000
 Age, years54.0 ± 9.269.7 ± 7.1<0.001
 HTN (%)2 (11.1)25 (78.1)<0.001
 DM (%)2 (11.1)10 (31.3)0.170
 Stroke/TIA prior (%)0 (0.0)4 (12.5)0.283
 Vascular disease (%)3 (16.7)29 (90.6)<0.001
pAF/psAF13/517/150.237
Time of AF history, years0.7 (0.2, 2.5)1.5 (0.2, 5.8)0.460
BMI, kg/m226.3 (24.0, 29.3)26.5 (23.6, 28.4)0.952
LVEDD, mm47.3 ± 3.647.2 ± 3.70.938
LVESD, mm28.5 (27.5, 31.3)29.0 (27.0, 33.0)0.654
LVEF (%)67.7 ± 5.066.6 ± 6.30.548
LAE (%)9 (50.0)21 (65.6)0.242
TC, mmol/L4.6 ± 1.03.8 ± 1.00.009
LDL-C, mmol/L2.6 ± 0.72.2 ± 0.90.073
HDL-C, mmol/L1.1 ± 0.41.1 ± 0.30.950
TG, mmol/L3.1 ± 5.41.4 ± 0.50.185
AST, U/L22.0 ± 12.620.6 ± 5.80.600
ALT, U/L26.9 ± 15.921.5 ± 10.50.201
TBil, μmol/L12.2 (10.1, 20.3)14.6 (10.0, 26.5)0.664
sCr, μmol/L69.7 ± 13.372.9 ± 19.50.531
UA, μmol/L341.3 ± 71.5327.0 ± 68.60.489
WBC, ×109/L5.7 ± 1.66.3 ± 1.40.206
HGB, g/L141.9 ± 17.1135.0 ± 13.50.122
PLT, ×109/L218.2 ± 46.7213.6 ± 48.70.748
ALB, g/L41.2 ± 2.939.5 ± 2.90.055
FBG, mmol/L4.9 (4.4, 5.6)5.2 (4.6, 6.0)0.322
HbA1c (%)6.0 ± 0.96.3 ± 0.70.348

Data are expressed as mean ± SD, median (first quartile, third quartile). AF, atrial fibrillation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; BMI, body mass index; DM, diabetes mellitus; FBG, fasting blood glucose; HTN, hypertension; HGB, hemoglobin; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LVEDD, left ventricular and diastolic diameter; LVESD, left ventricular and systolic systolic diameter; LVEF, left ventricular ejection fraction; LAE, left atrial enlargement, pAF, paroxysmal atrial fibrillation; psAF, persistent atrial fibrillation; PLT, platelet; sCr, serum creatinine; TC, total cholesterol; TG, triglyceride; TIA, transient ischemic attack; LDL-C, low-density lipoprotein cholesterol; TBil, total bilirubin; UA, uric acid, WBC white blood cell.