The Impact of Optical Coherence Tomography in the Early Identification of Children with Sickle Cell Retinopathy

Table 4

Relation between eye abnormalities by fundus examination and different study variables.

Variables		Eye abnormalities n = 12 (%) (7 children)	No eye abnormalities n = 18 (%) (8 children)	-value
Disease duration (years)		10.0 ± 1.0	8.7 ± 1.4	0.009
Hb F (%) prior to study		6.58 ± 0.9	9.61 ± 4.2	0.021
Retics (%) prior to study		10.37 ± 1.4	8.58 ± 2.6	0.039
Exchange transfusion ^1	One time (suspected stroke)	1/7 (14.3)	0/8 (0.0)	0.117
	One time (acute chest syndrome)	2/7 (28.6)	0/8 (0.0)
Painful crisis	Frequent	8 (66.7)	4 (22.2)	0.020
	Infrequent	4 (33.3)	8 (44.4)
Hydroxyurea therapy ^2	Not compliant	5/7 (71.4)	0/8 (0.0)	0.010
	Compliant	2/7 (28.6)	5/8 (62.5)

¹Occurred in 3 children, all with eye abnormalities by fundus examination. ²Prescribed in 12 children, 7 with eye abnormalities and 5 without abnormalities by fundus examination.