The Impact of Optical Coherence Tomography in the Early Identification of Children with Sickle Cell Retinopathy

Table 5

Relation between eye abnormalities by OCT and OCTA and different study variables.

Variables		Eye abnormalities (macular thinning and flow void at the deep retinal capillary plexus) n = 10 (%) (7 children)	No eye abnormalities n = 20 (%) (8 children)	-value
Disease duration (years)		10.3 ± 1.35	9.02 ± 1.28	0.039
Hb F (%) prior to study		6.67 ± 0.52	8.83 ± 3.91	0.192
Retics (%) prior to study		11.0 ± 2.37	8.87 ± 2.21	0.047
Exchange transfusion ^1	One time (suspected stroke)	1/7 (14.3)	0/8 (0.0)	0.117
	One time (acute chest syndrome)	2/7 (28.6)	0/8 (0.0)
Painful crisis	Frequent	5 (50.0)	2 (10.0)	0.040
	Infrequent	2 (20.0)	4 (20.0)
Hydroxyurea therapy ^2	Not compliant	4/7 (57.1)	1/8 (12.5)	0.046
	Compliant	1/7 (14.3)	6/8 (75.0)

¹Occurred in 3 children; all with eye abnormalities by OCT. ²Prescribed in 12 children; 7 with eye abnormalities and 5 without abnormalities by OCT.