Changes in Early T-Cell Subsets and Their Impact on Prognosis in Patients with Sepsis: A Single-Center Retrospective Study

Table 3

Prognostic comparison between different T-cell count groups in sepsis patients.

	CD3^+T-cell counts			CD4^+T-cell counts			CD8^+T-cell counts			CD4^+/CD8^+ ratio
	CD3^+ decreased group (n = 157)	CD3^+ nondecreased group (n = 49)	value	CD4^+ decreased group (n = 158)	CD4^+ nondecreased group (n = 48)	value	CD8^+ decreased group (n = 131)	CD8^+ nondecreased group (n = 75)	value	CD4^+/CD8^+ nondecreased group (n = 161)	CD4^+/CD8^+ decreased group (n = 45)	value
Age, mean ± SD, years	63.53 ± 15.82	57.61 ± 16.15	0.02	63.73 ± 15.62	56.85 ± 16.53	0.01	64.06 ± 15.64	58.75 ± 16.33	0.02	62.18 ± 15.44	61.91 ± 18.30	0.91
Length of ICU stay, median, [IQR], d	11.00 (4.5, 21.0)	7.00 (4.0, 17.0)	0.03	8 (4, 14)	8.00 (4.00, 13.0)	0.88	7 (4.0, 14.0)	9.00 (5.0, 18.0)	0.12	8.0 (4.0, 15.0)	8.0 (4.0, 19.0)	0.69
APACHE II score, mean ± SD	16.90 ± 6.83	14.39 ± 5.62	0.01	16.72 ± 6.65	14.92 ± 6.47	0.10	17.05 ± 6.61	15.00 ± 6.51	0.03	16.31 ± 6.65	16.27 ± 6.65	0.96
SOFA score, median, [IQR]	7.00 (4.00, 9.00)	6.00 (4.00, 9.00)	0.88	6.00 (4.00, 10.00)	6.00 (3.00, 9.00)	0.13	6.00 (4.00, 9.00)	6.00 (4.00, 10.00)	0.92	6.00 (4.00, 9.00)	7.00 (5.00, 10.00)	0.11
Shock, n (%)	82 (52.22%)	22 (44.89%)	0.73	81 (51.27%)	23 (47.92%)	0.74	60 (45.8%)	44 (58.7%)	0.08	79 (49.1%)	25 (55.6%)	0.50
MV, n (%)	102 (67.5%)	25 (51.0%)	0.04	96 (61.39%)	31 (64.58%)	0.73	81 (61.8%)	46 (61.3%)	1.0	63 (60.9%)	29 (64.4%)	0.73
ICU mortality, n (%)	29 (18.47%)	6 (12.24%)	0.34	25 (15.82%)	10 (20.83%)	0.84	26 (19.8%)	9 (12.0%)	0.18	27 (16.8%)	8 (17.8%)	0.82
28-day mortality, n (%)	45 (28.66%)	11 (22.45%)	0.39	43 (27.21%)	13 (27.08%)	0.99	40 (30.5%)	16 (45.7%)	0.11	41 (25.5%)	15 (33.3%)	0.29
1-year mortality, n (%)	65 (41.4%)	17 (34.7%)	0.50	63 (39.9%)	19 (39.6%)	0.97	53 (40.5%)	29 (38.7%)	0.88	59 (36.6%)	23 (51.1%)	0.09
3-year survival, n (%)	76 (47.8%)	26 (53.1%)	0.62	76 (48.1%)	25 (52.1%)	0.38	62 (47.3%)	39 (52.0%)	0.31	86 (53.4%)	15 (33.3%)	0.01

SD, standard deviation; APACHE, acute physiology and chronic health evaluation; IQR, interquartile range; MV, mechanical ventilation.