Quality of Life, Procedural Success, and Clinical Outcomes following Transcatheter Mitral Valve Repair

Table 1

Baseline characteristics of the study cohort.

	<25 N = 48	25–49 N = 96	50–74 N = 141	≥75 N = 270	values
Age (median, IQR)	80 (74–84)	79 (71–85)	82 (75–88)	77 (71–85)	0.024
Female (n, %)	21 (44)	50 (52)	63 (44)	97 (36)	0.036
BMI (median, IQR)	24 (21–29)	24 (21–27)	25 (22–28)	24 (21–27)	0.61
Hypertension (n, %)	43 (90)	74 (77)	125 (89)	218 (81)	0.046
Diabetes (n, %)	16 (33)	23 (24)	33 (23)	56 (21)	0.29
Previous CVA/TIA (n, %)	5 (10)	5 (5)	7 (5)	18 (7)	0.66
Length of hospitalization (median, IQR)	1 (1–4)	1 (1–4)	1 (1–1)	1 (1–1)	<0.001
Previous PCI (n, %)	15 (31)	28 (29)	37 (26)	59 (22)	0.33
Previous CABG (n, %)	18 (38)	23 (24)	24 (17)	51 (19)	0.015
Prior MI (n, %)	9 (19)	27 (28)	18 (13)	33 (12)	0.002
Baseline creatinine (median, IQR)	1.2 (0.9–1.6)	1.2 (1–1.8)	1.2 (1–1.6)	1.2 (0.9–1.6)	0.44
Baseline hemoglobin (mean ± SD)	11.5 ± 1.9	11.9 ± 2	12.3 ± 2	12.6 ± 1.8	<0.001
Baseline BNP (median, IQR)	586 (320–1428)	444 (251–1076)	472 (229–1054)	379 (160–922)	0.044
NYHA class (n, %) prior
2	18 (41)	51 (58)	90 (67)	107 (42)	<0.001
3	21 (48)	26 (30)	18 (13)	12 (5)
4	2 (5)	1 (1)	1 (1)	1 (0.4)
Previous A.fib/flutter (n, %)	32 (67)	50 (52)	96 (68)	137 (51)	0.003
STS risk score-mitral valve repair (median, IQR)	7 (4.5.9.9)	5 (2.6–8.2)	6 (3.2–8.7)	4 (2.1–6.9)	<0.001
Functional MR (n, %)	31 (65)	58 (60)	79 (56)	117 (43)	0.002
LVEF (mean ± SD)	46 ± 16	47 ± 19	51 ± 17	52 ± 16	0.036
Systolic PAP (mean ± SD)	47 ± 19	47 ± 18	46 ± 17	43 ± 19	0.35
LVEDD (mean ± SD)	5.3 ± 1.0	5.4 ± 1.0	5.2 ± 1.1	5.4 ± 0.9	0.22
LVESD (mean ± SD)	3.9 ± 1.1	4.1 ± 1.5	3.8 ± 1.3	3.9 ± 1.1	0.24
LVEDV (median, IQR)	101 (70–153)	101 (63–177)	89 (61–131)	110 (78–152)	0.08
LVESV (median, IQR)	50 (26–85)	45 (25–108)	38 (24–75)	54 (29–92)	0.15
LAVI (median, IQR)	50 (40–78)	58 (41–71)	58 (43–76)	57 (44–72)	0.82
TR
Trivial/none	11 (23)	10 (10)	18 (13)	43 (16)	0.033
Mild	9 (19)	27 (28)	35 (25)	88 (33)
Moderate	16 (33)	33 (34)	51 (36)	89 (33)
Severe	11 (23)	26 (27)	37 (26)	50 (19)
TAPSE (mean ± SD)	1.6 ± 0.4	1.6 ± 0.4	1.7 ± 0.5	1.8 ± 0.5	0.11

BMI-body mass index, CVA/TIA-cerebrovascular accident/transient ischemic attack, PCI-percutaneous coronary intervention, CABG-coronary artery bypass grafting, MI-myocardial infarction, BNP-brain natriuretic peptide, NYHA-New York heart association, A.fib-atrial fibrillation, LVEF-left ventricular ejection fraction, PAP-pulmonary artery pressure, LVEDD-left ventricular end-diastolic diameter, LVESD-left ventricular end-systolic diameter, LVEDV-left ventricular end-diastolic volume, LVESV-left ventricular end-systolic volume, LAVI-left atrial volume index, TR-tricuspid regurgitation, TAPSE-tricuspid annular plane systolic excursion. NYHA class was available in 521 patients.