Propofol Regulates ER Stress to Inhibit Tumour Growth and Sensitize Osteosarcoma to Doxorubicin

Figure 4

Bioinformatic analysis showed that propofol treatment led to endoplasmic reticulum stress. Transcriptional data of GSE101724 were downloaded from the GEO database and differentially expressed genes after propofol (300 μM) treatment were functionally analysed. Differentially expressed genes were shown in the volcano plot (a) with up- and downregulated genes labelled as red or blue, respectively. GO functional enrichment of the differential expressed genes showed enrichment in the endoplasmic reticulum stress-related pathways (b). The top 10 up- or downregulated genes after propofol treatment were plotted as the heatmap (c).

(a)

(b)

(c)