Variation of Bone Turnover Markers in Childhood and Adolescence

Table 1

Bone metabolism indices and basic indices during growth in children.

		Age (years)	25(OH) vitamin D (ng/mL)	P1NP (ng/mL)	β-CTx(pg/mL)	N-MID (ng/mL)	ALP(U/L)	Ca (mmol/L)	Pi(mmol/L)
Boys (n = 366)	Preschool (n = 142)	3 (1, 5)	31. 6 (27.1, 38.8)	798 (577, 1241)	1350 (1140, 1620)	59.8 (48.7, 71.7)	263.5 (207, 348)	2.46 (2.37, 2.54)	1.68 (1.58, 1.90)
	Preadolescence (n = 183)	8 (7, 10)	24.4 (18.5, 30.1)	644 (483, 886)	1550 (1250, 1880)	63.4 (52.8, 83.9)	242 (201, 291)	2.38 (2.32, 2.44)	1.67 (1.57, 1.77)
	Adolescence (n = 41)	13 (12, 14)	24.3 (18.6, 28.9)	755 (502, 1058)	1850 (1283, 1990)∗	78.5 (56.9, 106.3)^†	312 (208, 467)^†	2.41 (2.27, 2.47)	1.69 (1.62, 1.77)
Girls (n = 295)	Preschool (n = 124)	3 (2, 3)	31.6 (27.1, 38.8)	767 (552, 1150)	1290 (923, 1540)	52.1 (43.7, 61.7)	257 (205, 324)	2.48 (2.43, 2.56)	1.76 (1.64, 1.9)
	Preadolescence (n = 91)	7 (6, 8)	24.4 (18.5, 30.1)	728 (490, 1024)	1385 (1089, 1878)	67.2 (52.0, 84.0)	240 (199, 287)	2.4 (2.32, 2.46)	1.67 (1.52, 1.73)
	Adolescence (n = 80)	12 (11, 12)	24.3 (18.6, 28.9)	580 (401, 788)	1303 (972, 1720)	62.3 (43.2, 85.9)	244 (174, 336)	2.37 (2.31, 2.44)	1.53 (1.43, 1.72)

Note: compared with the preschool group,  < 0.05; ^†compared with the preadolescence group,  < 0.05.