The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study
Table 1
Basic characteristics of the overall population by the severity of OSA.
Characteristics
Non-OSA (N = 101)
Mild OSA (N = 120)
Moderate OSA (N = 147)
Severe OSA (N = 535)
for linear trend
Age (years)
47 (47–60)
60 (47–62)
47 (47–62)
47 (47–60)
0.239
BMI (kg/m2)
25.7 (22.7–29.3)
26.7 (23.4–30.0)
27.6 (25.0–30.2)
28.7 (26.0–30.9)
<0.001
NC (cm)
39 (35–41)
40 (37–42)
41 (38–43)
41 (40–44)
<0.001
WC (cm)
93 (84–102)
96 (87–106)
99 (92–107)
101 (95–108)
<0.001
HC (cm)
99 (91–104)
101 (95–107)
102 (97–108)
103 (99–109)
<0.001
WHR
0.94 (0.89–0.99)
0.96 (0.91–0.99)
0.96 (0.93–1.01)
0.97 (0.94–1.01)
<0.001
Smoking (n (%))
34 (34.7)
34 (30.1)
69 (47.9)
303 (59.4)
<0.001
Drinking (n (%))
36 (36.7)
39 (34.5)
77 (53.5)
302 (59.3)
<0.001
Haematological parameters
PLT (×103/μL)
223 (180–273)
219 (186–260)
206 (178–256)
220 (183–257)
0.046
MPV (fL)
10.7 (10–11.5)
10.6 (9.9–11.4)
10.6 (10–11.5)
10.6 (9.9–11.5)
0.97
PDW (fL)
13 (11.3–14.6)
12.7 (11.4–14.2)
13.1 (11.7–15.4)
13.4 (11.9–16)
<0.001
APTT (s)
26.8 (24–28.8)
27.1 (11.4–14.2)
25 (23.5–27.8)
25.3 (23.3–27.8)
<0.001
TT (s)
18.1 (17.1–19.3)
18.5 (17.8–19.1)
18.4 (17.9–19.1)
18.5 (17.7–19.2)
0.697
PT (s)
11 (10.6–11.4)
10.9 (10.6–11.5)
10.8 (10.3–11.4)
10.9 (10.4–11.4)
0.196
Breath parameters
Minimum SaO2 (%)
90 (87–93)
88 (83–90)
82 (78–86)
69 (60–76)
<0.001
AHI
2.5 (1.5–3.6)
9.7 (6.6–12.4)
21.7 (18.3–25.9)
58.7 (44.6–72.7)
<0.001
ODI
3.1 (2.1–4.5)
9.5 (6.3–12.7)
22.7 (17.7–28.0)
59.2 (43.9–74.6)
<0.001
MAI
15.1 (10.8–24.8)
17.6 (12–25.9)
21.4 (15.0–30.0)
34.7 (19.2–53.2)
<0.001
CT90
0.06 (0.00–4.02)
2.19 (0.15–14.64)
5.20 (2.13–13.95)
21.92 (9.00–39.70)
<0.001
Data are presented as median with interquartile range. BMI, body mass index; PLT, platelet; MPV, mean platelet volume; PDW, platelet distribution width; APTT, activated partial thromboplastin time; TT, thrombin time; PT, prothrombin time; AHI, apnoea-hypopnea index; ODI, oxygen desaturation index; MAI, microarousal index; CT90, percentage of sleep time with oxygen saturation below 90%. The bold values indicate a statistical significance (p<0.05).
