International Journal of Clinical Practice

Research Article

The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study

Table 3

Associations of OSA-related traits with the risk of coagulation.


	PDW			APTT			TT
	OR	95% CI		OR	95% CI		OR	95% CI

Model 1
Minimum SaO₂ (%)	0.988	0.977–1.000	0.056	0.993	0.967–1.020	0.593	1.056	1.013–1.100	0.01
AHI	1.008	1.002–1.015	0.015	1.002	0.988–1.017	0.755	0.984	0.967–1.001	0.07
ODI	1.010	1.003–1.016	0.003	1.005	0.991–1.019	0.519	0.985	0.968–1.001	0.073
MAI	1.007	0.999–1.015	0.084	1.009	0.993–1.025	0.275	0.978	0.956–1.002	0.071
CT90	1.004	0.996–1.012	0.301	0.991	0.971–1.011	0.391	0.976	0.949–1.004	0.089

Model 2
Minimum SaO₂ (%)	0.990	0.978–1.002	0.093	0.994	0.967–1.021	0.645	1.053	1.010–1.098	0.014
AHI	1.007	1.001–1.014	0.027	1.002	0.987–1.017	0.799	0.985	0.968–1.003	0.098
ODI	1.009	1.003–1.016	0.006	1.004	0.990–1.019	0.565	0.986	0.969–1.003	0.106
MAI	1.006	0.999–1.014	0.107	1.009	0.993–1.025	0.299	0.979	0.956–1.003	0.085
CT90	1.004	0.996–1.012	0.347	0.991	0.970–1.011	0.364	0.977	0.950–1.005	0.107

Model 3
Minimum SaO₂ (%)	0.991	0.979–1.003	0.147	0.996	0.970–1.023	0.786	1.055	1.013–1.099	0.011
AHI	1.007	1.000–1.013	0.053	1.000	0.985–1.014	0.984	0.983	0.966–1.000	0.053
ODI	1.009	1.002–1.015	0.008	1.002	0.988–1.016	0.784	0.983	0.966–1.000	0.05
MAI	1.007	0.999–1.015	0.082	1.007	0.991–1.023	0.413	0.978	0.955–1.002	0.068
CT90	1.003	0.995–1.011	0.490	0.989	0.968–1.009	0.283	0.973	0.946–1.001	0.062

Model 4
Minimum SaO₂ (%)	0.989	0.977–1.001	0.074	0.994	0.968–1.021	0.662	1.051	1.008–1.095	0.019
AHI	1.008	1.001–1.015	0.022	1.002	0.987–1.017	0.797	0.986	0.969–1.004	0.117
ODI	1.009	1.003–1.016	0.005	1.004	0.990–1.018	0.587	0.987	0.970–1.004	0.123
MAI	1.007	0.999–1.014	0.103	1.010	0.994–1.026	0.237	0.978	0.955–1.002	0.073
CT90	0.977	0.950–1.005	0.104	0.991	0.971–1.011	0.381	0.977	0.950–1.005	0.104

Model 5
Minimum SaO₂ (%)	0.990	0.978–1.003	0.123	0.993	0.967–1.021	0.637	1.050	1.007–1.094	0.021
AHI	1.007	1.000–1.014	0.058	1.002	0.987–1.017	0.832	0.985	0.968–1.003	0.103
ODI	1.009	1.002–1.016	0.009	1.004	0.990–1.019	0.578	0.986	0.968–1.003	0.103
MAI	1.007	0.999–1.015	0.100	1.008	0.992–1.025	0.323	0.979	0.956–1.002	0.076
CT90	1.003	0.994–1.011	0.517	0.990	0.970–1.011	0.346	0.975	0.948–1.003	0.083

Model 1 was adjusted for age, BMI; model 2 was adjusted for variables included in model 1 and hypertension; model 3 was adjusted for age, waist-hip ratio, and hypertension; model 4 was further adjusted for smoking and drinking based on model 2; model 5 was adjusted for variables in model 4 and additional waist-hip ratio. PDW, platelet distribution width; APTT, activated partial thromboplastin time; TT, thrombin time; AHI, apnoea-hypopnea index; ODI, oxygen desaturation index; MAI, microarousal index; CT90, percentage of sleep time with oxygen saturation below 90%. The bold values indicate a statistical significance (p<0.05).