Relationship between Body Mass Index and Bone Turnover Markers in Girls with Idiopathic Central Precocious Puberty

Table 3

Blood biochemical characteristics of participants.

Items	Normal weight (n = 89)	Overweight (n = 70)	Obese (n = 52)	value
ALP (U/L)	295.00 (259.00–352.00)	294.50 (254.00–365.00)	319.50 (246.00–366.00)	0.840
FBG (mmol/L)	4.61 (4.42–4.82)	4.63 (4.39–4.83)	4.70 (4.54–4.81)	0.417
IGF1 (ng/mL)	281.00 (207.50–342.50)	311.00 (235.00–389.00)	340.50 (273.00–381.00)^c	0.002
IGFBP-3 (μg/mL)	5.69 (5.19–6.35)	5.90 (5.37–6.57)^b	6.58 (5.94–7.04)^c	<0.001
HCY (μmol/L)	9.00 (7.85–10.15)	9.60 (8.20–10.70)^b	8.35 (6.90–9.70)	0.011
FT3 (pmol/L)	6.07 (5.80–6.42)	6.18 (5.86–6.49)	6.38 (5.99–6.68)^c	0.037
FT4 (pmol/L)	15.34 (14.47–17.16)^a	14.95 (13.74–15.90)	15.16 (13.69–16.73)	0.046
T3 (nmol/L)	2.21 (2.04–2.45)	2.25 (1.95–2.52)^b	2.30 (2.11–2.61)	0.148
T4 (nmol/L)	107.90 (93.50–123.85)	104.10 (88.70–115.10)	103.20 (92.30–111.70)	0.115
TSH (mIU/L)	2.33 (1.74–3.34)^a	1.87 (1.25–2.58)^b	2.69 (1.94–3.47)	0.001
TC (mmol/L)	3.78 (3.50–4.12)	3.73 (3.28–4.48)^b	3.83 (3.64–4.47)	0.169
TG (mmol/L)	0.80 (0.68–0.96)	0.86 (0.68–1.01)^b	0.82 (0.70–1.50)^c	0.073
HDL-C (mmol/L)	1.50 (1.35–1.81)	1.46 (1.30–1.69)	1.47 (1.25–1.68)	0.415
LDL-C (mmol/L)	2.11 (1.82–2.41)	2.11 (1.71–2.73)	2.24 (1.95–2.67)^c	0.088
VitD (ng/mL)	20.40 (17.45–23.45)^a	18.40 (15.00–23.60)	21.75 (15.60–24.60)	0.274
E2 (pg/ml)	22.80 (15.00–32.90)	21.00 (16.20–34.30)^b	26.40 (21.40–33.15)^c	0.073
LH-base (IU/L)	0.80 (0.50–1.20)	0.90 (0.60–1.50)^b	0.50 (0.30–1.10)	0.005
FSH-base (IU/L)	2.40 (1.40–3.40)	2.90 (1.50–3.70)	2.35 (2.00–3.30)	0.205
LH-peak (IU/L)	17.10 (12.35–23.10)^a	13.60 (9.00–18.70)^b	10.20 (8.20–14.20)^c	<0.001
FSH-peak (IU/L)	15.40 (12.25–18.20)^a	13.00 (10.60–16.30)	12.45 (11.00–15.60)^c	0.014
LH/FSH peak	1.10 (0.89–1.52)^a	0.90 (0.82–1.29)^b	0.79 (0.65–0.95)^c	<0.001

^aSignificantly different from the overweight group. ^bSignificantly different from the obese group. ^cSignificantly different from the normal weight group. ALP, alkaline phosphatase; FBG, fasting blood glucose; IGF1, insulin-like growth factor 1; IGFBP-3, insulin-like growth factor binding protein-3; HCY, homocysteine; FT3, free triiodothyronine; FT4, free thyroxine; T3, triiodothyronine; T4, thyroxine; TSH, thyroid-stimulating hormone; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; VitD, vitamin D; E2, estradiol; LH-base, luteinizing hormone base; FSH-base, follicular stimulating hormone base; LH-peak, luteinizing hormone peak; FSH-peak, follicular stimulating hormone peak; LH/FSH peak, luteinizing hormone/follicular stimulating hormone peak.