Association between Elevated Plasma Vitamin B12 and Short-Term Mortality in Elderly Patients Hospitalized in an Internal Medicine Unit
Table 1
Population characteristics.
Total, n = 330
Normal B12 (n = 165)
Elevated B12 (n = 165)
value
Clinical
Female
175 (53)
85 (51.5)
90 (54.5)
0.66
Age (years)
77 ± 15
79 ± 13
75 ± 16
0.047
Age of death (years)
84 ± 9
84 ± 9
83 ± 10
0.463
Weight (kg)
66 ± 18
68 ± 17
63 ± 16
0.008
BMI
25 ± 7
26 ± 7
23 ± 5
<0.001
From ICU
76 (23)
16 (10)
60 (36)
<0.001
Hospitalization duration (d)
20 ± 19
16 ± 15
23 ± 22
<0.001
Comorbidities
Liver diseases
41 (12)
16 (10)
25 (15)
0.181
Chronic kidney diseases
106 (32)
59 (36)
47 (29)
0.195
Blood cancers
21 (6)
7 (4)
14 (8)
0.175
Solid cancers
36 (11)
13 (8)
23 (14)
0.111
Chronic heart failure
143 (43)
73 (44)
70 (42)
0.739
Chronic lung diseases
77 (23)
45 (27)
32 (19)
0.118
Autoimmune diseases
27 (8)
8 (5)
19 (11)
0.043
Diabetes mellitus
108 (33)
60 (36)
48 (29)
0.197
Dementia
86 (26)
50 (30)
36 (22)
0.103
Alcoholism
46 (14)
18 (11)
28 (17)
0.152
Biology
Hemoglobin (g/dl)
11 ± 2
11 ± 2
11 ± 2
0.49
MCV (fl)
92 ± 8
92 ± 8
93 ± 9
0.36
B9 (nmol/l)
22 ± 21
18 ± 18
25 ± 23
0.006
B12 (pmol/l)
634 ± 490
301 ± 87
967 ± 502
<0.001
Creatinine (μmol/l)
126 ± 97
134 ± 106
117 ± 87
0.122
eGFR (ml/min/1.73 m2)
57 ± 29
53 ± 27
61 ± 31
0.018
Albumin (g/l)
34 ± 5
35 ± 5
33 ± 5
0.001
Ferritin (median-IQR) (μg/l)
286 [153–568]
215 [126–416]
404 [211–730]
<0.001
Transferrin saturation (%)
21 ± 20
19 ± 16
22 ± 23
0.132
CRP (median-IQR) (mg/l)
46 [13–119]
42 [11–118]
49 [17–124]
0.101
Treatments
Numbers of treatment
7 ± 4
7 ± 3
6 ± 4
0.003
Proton pump inhibitors
149 (45)
78 (47)
71 (43)
0.507
Metformin
39 (12)
25 (15)
14 (9)
0.087
Data are shown as mean ± standard deviation, median (interquartile range), or n (percentage). BMI = body mass index, kg/m2; ICU = intensive care unit; MCV = mean corpuscular volume; eGFR = estimated glomerular filtration rate; CRP = C-reactive protein. Bold p values are < 0.05.
