Research Article

Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough

Table 2

Comparison of MII-pH variables between responders and nonresponders.

ItemResponders (n = 50)Nonresponders (n = 40)

AET (%)1.05 (0.45, 3.00)1.11 (0.41, 3.38)0.669
PSWPI38.68 ± 9.9950.92 ± 5.390.332
MNBI1817.75 ± 259.262369.93 ± 326.350.030
Proximal MNBI1833.39 ± 92.162742.57 ± 204.64≤0.001
Distal MNBI2095.16 ± 266.622778.37 ± 286.620.095
SAP (%)85.80 (73.80, 96.70)90.35 (65.40, 98.25)0.508
Acid SAP (%)20.90 (7.00, 35.58)24.50 (13.05, 36.05)0.418
Nonacid SAP (%)85.50 (65.50, 96.25)7.00 (0.00, 91.90)0.101
SI (%)22.50 (5.00, 35.13)20.00 (0.00, 33.30)0.857
Total reflux (n)90.00 (29.00, 148.00)58.10 (36.20, 91.00)0.284
Acid reflux (n)20.90 (7.00, 35.58)24.95 (13.33, 36.63)0.340
Weakly acid reflux (n)56.00 (31.70, 86.00)14.00 (14.00, 44.20)0.022
Weakly alkaline reflux (n)8.75 (1.83, 24.75)10.15 (1.60, 18.48)0.907
Nonacid reflux (n)61.35 (15.90.86.50)21.60 (0.00, 52.50)0.008
Gas reflux (n)20.00 (10.40, 44.00)11.10 (4.85, 24.00)0.059
Liquid reflux (n)20.60 (8.75, 32.00)17.00 (9.00, 28.80)0.610
Mixed reflux (n)45.00 (14.90, 67.50)37.60 (17.40, 56.00)0.905
Proximal extent (n)19.00 (5.04, 24.00)5.50 (2.56, 11.13)0.011
Acid clearance (s)10.50 (7.13, 13.00)12.00 (10.50, 12.00)0.307

Note: MNBI, mean nocturnal baseline impedance; PSPWI, postreflux swallow-induced peristaltic wave index; SAP, symptom association probability; SI, symptom index; AET, acid exposure time.