The Prognostic Value and Potential Mechanism of Tumor-Nutrition-Inflammation Index and Genes in Patients with Advanced Lung Cancer

Table 1

Clinical characteristics of the patients with different AGR and SIRI according to the optimized cut-off value in training dataset.

	No. of patients (N = 136)	AGR < 1.22 (N = 64)	AGR  1.22 (N = 72)	value	SIRI < 1.60 (N = 61)	SIRI  1.60 (N = 75)	value
Gender				0.492			0.002
Female	40 (29.4%)	17 (26.6%)	23 (31.9%)		26 (42.6%)	14 (18.7%)
Male	96 (70.6%)	47 (73.4%)	49 (68.1%)		35 (57.4%)	61 (81.3%)
Age				0.089			0.875
60	37 (27.2%)	13 (20.3%)	24 (33.3%)		17 (27.9%)	20 (26.7%)
>60	99 (72.8%)	51 (79.7%)	48 (66.7%)		44 (72.1%)	55 (73.3%)
History of LC operation				0.005			0.135
No	102 (75.0%)	55 (85.9%)	47 (65.3%)		42 (68.9%)	60 (80.0%)
Yes	34 (25.0%)	9 (14.1%)	25 (34.7%)		19 (31.1%)	15 (20.0%)
Differentiation				0.172			0.078
Poor	36 (26.5%)	19 (29.7%)	17 (23.6%)		12 (19.7%)	24 (32.0%)
Moderately well	13 (9.6%)	3 (4.7%)	10 (13.9%)		9 (14.8%)	4 (5.3%)
Unknown	87 (64.0%)	42 (65.6%)	45 (62.5%)		40 (65.6%)	47 (62.7%)
Pathology				0.7			0.008
Adenocarcinoma	72 (52.9%)	35 (54.7%)	37 (51.4%)		40 (65.6%)	32 (42.7%)
Nonadenocarcinoma	64 (47.1%)	29 (45.3%)	35 (48.6%)		21 (34.4%)	43 (57.3%)
Mutation				0.822			0.204
Positive	56 (41.2%)	28 (43.8%)	28 (38.9%)		30 (49.2%)	26 (34.7%)
Negative	41 (30.1%)	19 (29.7%)	22 (30.6%)		17 (27.9%)	24 (32.0%)
Unknown	39 (28.7%)	17 (26.6%)	22 (30.6%)		14 (23.0%)	25 (33.3%)
Bone metastasis				0.763			0.179
No	114 (83.8%)	53 (82.8%)	61 (84.7%)		54 (88.5%)	60 (80.0%)
Yes	22 (16.2%)	11 (17.2%)	11 (15.3%)		7 (11.5%)	15 (20.0%)
Brain metastasis				0.869			0.596
No	114 (83.8%)	54 (84.4%)	60 (83.3%)		50 (82.0%)	64 (85.3%)
Yes	22 (16.2%)	10 (15.6%)	12 (16.7%)		11 (18.0%)	11 (14.7%)
Adrenal metastasis				0.413			0.707
No	124 (91.2%)	57 (89.1%)	67 (93.1%)		55 (90.2%)	69 (92.0%)
Yes	12 (8.8%)	7 (10.9%)	5 (6.9%)		6 (19.8%)	6 (8.0%)
Liver metastasis				0.514			0.097
No	123 (90.4%)	59 (92.2%)	64 (88.9%)		58 (95.1%)	65 (86.7%)
Yes	13 (9.6%)	5 (7.8%)	8 (11.1%)		3 (4.9%)	10 (13.3%)
History of smoke				0.479			0.112
No	70 (51.5%)	35 (54.7%)	35 (48.6%)		36 (59.0%)	34 (45.3%)
Yes	66 (48.5%)	29 (45.3%)	37 (51.4%)		25 (41.0%)	41 (54.7%)
History of alcohol				0.427			0.619
No	102 (75.0%)	50 (78.1%)	52 (72.2%)		47 (77.0%)	55 (73.3%)
Yes	34 (25.0%)	14 (21.9%)	20 (27.8%)		14 (23.0%)	20 (26.7%)
Hypertension				0.444			0.264
No	89 (65.4%)	44 (68.8%)	45 (62.5%)		43 (70.5%)	46 (61.3%)
Yes	47 (34.6%)	20 (31.2%)	27 (37.5%)		18 (29.5%)	29 (38.7%)
Diabetes				0.606			0.881
No	121 (89.0%)	56 (87.5%)	65 (90.3%)		54 (88.5%)	67 (89.3%)
Yes	15 (11.0%)	8 (12.5%)	7 (9.7%)		7 (11.5%)	8 (10.7%)
BMI				0.008			0.407
<18.5	12 (8.8%)	10 (15.6%)	2 (2.8%)		4 (6.6%)	8 (10.7%)
18.5	124 (91.2%)	54 (84.4%)	70 (97.2%)		57 (93.4%)	67 (89.3%)
CEA				0.018			0.88
5	57 (41.9%)	20 (31.2%)	37 (51.4%)		26 (42.6%)	31 (41.3%)
>5	79 (58.1%)	44 (68.8%)	35 (48.6%)		35 (57.4%)	44 (58.7%)
CA199				0.078			0.602
43	95 (69.9%)	40 (62.5%)	55 (76.4%)		44 (72.1%)	51 (68.0%)
>43	41 (30.1%)	24 (37.5%)	17 (23.6%)		17 (27.9%)	24 (32.0%)
SCC				0.113			0.361
1.5	88 (64.7%)	37 (57.8%)	51 (70.8%)		42 (68.9%)	46 (61.3%)
>1.5	48 (35.3%)	27 (42.2%)	21 (29.2%)		19 (31.0%)	29 (38.7%)
AFP				0.734			0.589
7	111 (81.6%)	53 (82.8%)	58 (80.6%)		51 (83.6%)	60 (80.0%)
>7	25 (18.4%)	11 (17.2%)	14 (19.4%)		10 (16.4%)	15 (20.0%)
CRP				<0.001			<0.001
5.5	63 (46.3%)	14 (21.9%)	49 (68.1%)		40 (65.6%)	23 (30.7%)
>5.5	73 (53.7%)	50 (78.1%)	23 (31.9%)		21 (34.4%)	52 (69.3%)