Age and Serum Creatinine Can Differentiate Wilson Disease Patients with Pseudonormal Ceruloplasmin

Table 3

Baseline characteristics of WD patients in training sets of groups A and B.

Variables	Group A	Group B	^†
N	43	49
Sex (male, %)	25 (58.1%)	38 (77.6%)	0.048
Age	25.3 ± 12.8	50.0 (38.6, 53.5)	≤0.001
Serum Cp (mg/L)	180.3 (152.4, 215.2)	245.5 ± 75.1	0.002
Complete blood count
WBC (×109/L)	4.8 ± 2.0	4.2 ± 2.0	0.089
PLT (×109/L)	177.7 ± 104.2	103.0 (54.0, 189.0)	0.026
ALT (IU/L)	45.0 (22.0, 96.0)	86.0 (20.5, 183.0)	0.210
AST (IU/L)	46.0 (22.0, 70.0)	44.0 (27.5, 101.0)	0.606
γ-GT (IU/L)	54.0 (29.0, 99.0)	68.0 (30.0, 167.5)	0.370
AP (IU/L)	112.5 (84.3, 246.0)	92.0 (77.5, 144.0)	0.040
CHE (IU/L)	5372.1 ± 2551.2	4488.0 (3151.5, 6931.5)	0.806
Albumin (g/L)	39.3 ± 8.2	36.3 ± 8.2	0.091
Total bilirubin (μmol/L)	16.4 (10.9, 26.3)	17.3 (12.0, 45.1)	0.075
Cr (μmol/L)	46.7 ± 18.5	71.1 ± 18.2	≤0.001
CHO (mmol/L)	4.3 ± 0.9	3.5 ± 1.2	0.001
PT (s)	13.4 (12.3, 16.6)	13.9 ± 2.3	0.237
INR	1.1 (1.0, 1.4)	1.2 ± 0.2	0.748
Liver cirrhosis	26 (60.5%)	25 (51.0%)	0.364
Child-Pugh scores	5 (5, 8)	6 (5, 7)	0.638
Class A (n)	31	27	0.094
Classes B and C (n)	12	22

^† values of univariate binary logistic regression analysis, depending on whether it is WD or not. The normal distribution parameters are shown as a mean ± standard deviation or else a median and quantile (25%, 75%). Cp, ceruloplasmin; WBC, white blood cell; PLT, platelet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; γ-GT, γ-glutamyltransferase; AP, alkaline phosphatase; CHE, cholinesterase; Cr, creatinine; CHO, cholesterol; PT, prothrombin time; INR, international normalised ratio.