Retinal Microvascular Density and Perfusion during an Insulin-Induced Hypoglycemia Episode: A Warning Call

Table 2

Vascular reactivity to hypoglycemia event.

3 × 3 mm protocol	Vascular perfusion (%)				Vascular density (%)
Stages	Healthy (n = 42)	DM without DR (n = 37)	DM with DR (n = 18)	value	Healthy (n = 42)	DM without DR (n = 37)	DM with DR (n = 18)	value
Baseline	34.58 (3.5)	33.54 (2.79)	31.08 (4.38)	0.009	19.62 (1.46)	18.54 (2.02)	16.85 (3.28)	0.002
Hypoglycemia	32.42 (3.74)	31.71 (3.77)	29.46 (4.46)	0.095	18.46 (2.32)	17.73 (2.58)	16.08 (3.04)	0.034
Return to normoglycemia	33.83 (2.74)	33.08 (4.1)	30.15 (4.24)	0.016	19.17 (1.6)	18.42 (2.5)	16.38 (2.98)	0.004
value	0.011	0.011	0.001		0.041	0.016	0.094

SD: standard deviation; IQR: interquartile range; DM: diabetes mellitus. Bold values represent the statistically significant values (P < 0.05).