Vitreoretinal Traction Syndrome, Nitrituria and Human Epidermal Growth Factor Receptor Negative Might Occur in the Aromatase-Inhibitor Anastrozole Treatment

Table 1

Four major algorithms in this study to assess potential associations between anastrozole and AEs.

Algorithms	Equation	Criterion
ROR	ROR = ad/b/c, 95% CI =	Lower limit of 95% CI > 1, N ≥ 3
PRR	PRR = a (c + d)/c/(a + b),  = [(ad − bc)^2](a + b + c + d)/[(a + b) (c + d) (a + c) (b + d)]	PRR ≥ 2,  ≥ 4, N ≥ 3
BCPNN	IC = log2a (a + b + c + d)/[(a + c) (a + b)], 95% CI = E (IC) ± 2V (IC)^0.5	IC025 > 0
MGPS	EBGM = a(a + b + c + d)/(a + c)/(a + b), 95% CI =	EBGM05 > 2

Notes: a: target AEs of Anastrozole; b: non-target-AEs of Anastrozole; c: target AEs of non-Anastrozole; d: non-target AEs of non-Anastrozole. Abbreviations: 95% CI, 95% confidence interval; N, the number of reports; , chi-squared; IC, information component; IC025, the lower limit of 95% CI of the IC; E (IC), the IC expectations; V (IC), the variance of IC; EBGM, empirical Bayesian geometric mean; EBGM05, the lower limit of 95% CI of EBGM.