Vitreoretinal Traction Syndrome, Nitrituria and Human Epidermal Growth Factor Receptor Negative Might Occur in the Aromatase-Inhibitor Anastrozole Treatment
Table 3
Signal strength of AEs of Anastrozole at the System Organ Class (SOC) level in FAERS source ranked by rank-sum approch.
SOC code
SOC
Case reports
ROR (95% CI)
PRR (95% CI)
IC (IC025)
EBGM (EBGM05)
10015919
Eye disorders
102
9.91 (8.14–12.07)
9.68 (7.99–11.73)
792.55
3.27 (2.62)
9.64 (7.92)
10038359
Renal and urinary disorders
51
9.52 (7.22–12.56)
9.41 (7.16–12.37)
382.33
3.23 (2.33)
9.38 (7.11)
10038738
Respiratory, thoracic and mediastinal disorders
194
9.66 (8.36–11.17)
9.23 (8.05–10.6)
1425.97
3.2 (2.72)
9.2 (7.96)
10022891
Investigations
285
9.64 (8.55–10.88)
9.01 (8.06–10.08)
2038.44
3.17 (2.76)
8.98 (7.96)
10007541
Cardiac disorders
79
8.78 (7.02–10.97)
8.62 (6.93–10.73)
531.28
3.1 (2.37)
8.59 (6.87)
10029205
Nervous system disorders
172
8.78 (7.53–10.23)
8.44 (7.29–9.77)
1129.14
3.07 (2.56)
8.41 (7.21)
10027433
Metabolism and nutrition disorders
116
7.7 (6.4–9.27)
7.51 (6.27–8.98)
654.37
2.9 (2.29)
7.48 (6.22)
10005329
Blood and lymphatic system disorders
402
7.99 (7.21–8.86)
7.27 (6.63–7.98)
2199.15
2.86 (2.51)
7.25 (6.54)
10028395
Musculoskeletal and connective tissue disorders
1319
10.16 (9.51–10.85)
7.07 (6.77–7.39)
7200.15
2.82 (2.61)
7.05 (6.6)
10018065
General disorders and administration site conditions
425
7.78 (7.03–8.6)
7.04 (6.44–7.7)
2230
2.81 (2.48)
7.02 (6.35)
10021428
Immune system disorders
147
6.68 (5.67–7.88)
6.47 (5.52–7.58)
681.73
2.69 (2.14)
6.45 (5.47)
10040785
Skin and subcutaneous tissue disorders
293
5.19 (4.61–5.85)
4.88 (4.37–5.45)
915.49
2.28 (1.89)
4.87 (4.32)
10037175
Psychiatric disorders
339
3.36 (3.01–3.76)
3.16 (2.85–3.5)
513.13
1.66 (1.29)
3.15 (2.82)
10017947
Gastrointestinal disorders
119
4.94 (4.12–5.93)
4.82 (4.04–5.76)
362.08
2.27 (1.66)
4.81 (4.01)
10077536
Product issues
39
3.12 (2.28–4.28)
3.1 (2.27–4.24)
55.71
1.63 (0.61)
3.1 (2.26)
10014698
Endocrine disorders
27
25.51 (17.43–37.33)
25.34 (17.36–36.99)
624.07
4.65 (3.43)
25.06 (17.12)
10010331
Congenital, familial and genetic disorders
18
24.64 (15.47–39.26)
24.53 (15.43–39)
401.79
4.6 (3.14)
24.27 (15.23)
10021881
Infections and infestations
20
23.49 (15.1–36.54)
23.38 (15.06–36.28)
423.86
4.53 (3.14)
23.14 (14.87)
10041244
Social circumstances
7
18.68 (8.87–39.34)
18.65 (8.87–39.23)
115.94
4.21 (2.04)
18.5 (8.78)
10047065
Vascular disorders
75
18.93 (15.05–23.82)
18.59 (14.84–23.28)
1238.78
4.2 (3.45)
18.44 (14.66)
10013993
Ear and labyrinth disorders
15
17.35 (10.43–28.87)
17.29 (10.41–28.71)
228.37
4.1 (2.52)
17.16 (10.31)
10029104
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
