Research Article

Vitreoretinal Traction Syndrome, Nitrituria and Human Epidermal Growth Factor Receptor Negative Might Occur in the Aromatase-Inhibitor Anastrozole Treatment

Table 4

The excerpted 40 signal strength of AEs of Anastrozole at preferred terms (PTs) level (Complete table contents were showed in Table S1).

Preferred terms (PTs)SOCCase reportsROR (95% CI)PRR (95% CI)IC (IC025)EBGM (EBGM05)

Vitreoretinal traction syndromeEye disorders151108.22 (593.69–2068.67)1103.98 (592.36–2057.51)9.51 (7.63)727.97 (389.98)
NitrituriaRenal and urinary disorders53561.82 (850.91–14909.47)3557.28 (850.4–14880.23)10.38 (6.97)1334.6 (318.83)
Human epidermal growth factor receptor negativeInvestigations6675.04 (269.45–1691.15)674.01 (269.33–1686.76)9 (6.34)512.49 (204.57)
Leiomyosarcoma recurrentNeoplasms benign, malignant and unspecified (incl cysts and polyps)4949.58 (292.3–3084.81)948.61 (292.25–3079.1)9.36 (6.11)657.04 (202.25)
Progesterone receptor assay positiveInvestigations6534.41 (218.33–1308.09)533.59 (218.23–1304.66)8.74 (6.13)427.07 (174.48)
Oestrogen receptor assay positiveInvestigations6400.81 (167.5–959.11)400.19 (167.43–956.56)8.4 (5.85)337.16 (140.9)
hER2 negative breast cancerReproductive system and breast disorders4502.72 (169.08–1494.71)502.2 (169.06–1491.84)8.67 (5.63)406.74 (136.8)
AnhidrosisSkin and subcutaneous tissue disorders13257.77 (144.87–458.66)256.91 (144.63–456.36)7.84 (6.06)229.42 (128.93)
Breast cancer recurrentReproductive system and breast disorders64165.3 (127.95–213.56)162.62 (126.37–209.27)7.24 (6.4)151.18 (117.02)
PseudocirrhosisHepatobiliary disorders16201.7 (120.7–337.07)200.88 (120.44–335.06)7.52 (5.91)183.69 (109.92)
Tongue cancer metastaticNeoplasms benign, malignant and unspecified (incl cysts and polyps)4341.85 (118.91–982.72)341.5 (118.9–980.8)8.2 (5.26)294.53 (102.46)
Oestradiol increasedInvestigations9218.79 (110.11–434.74)218.29 (110.01–433.12)7.63 (5.56)198.13 (99.71)
Joint neoplasmMusculoskeletal and connective tissue disorders4316.52 (110.7–905.02)316.2 (110.69–903.25)8.11 (5.19)275.53 (96.37)
Pelvic organ prolapseReproductive system and breast disorders6233.19 (100.34–541.93)232.84 (100.31–540.48)7.71 (5.26)210.04 (90.38)
Soft tissue neoplasmMusculoskeletal and connective tissue disorders5254.41 (100.6–643.38)254.09 (100.58–641.89)7.83 (5.18)227.17 (89.83)
Carbohydrate antigen 15-3 increasedInvestigations15163.14 (96.42–276.03)162.51 (96.23–274.46)7.24 (5.6)151.09 (89.29)
Trigger fingerMusculoskeletal and connective tissue disorders58124.64 (95.48–162.71)122.81 (94.43–159.72)6.86 (5.99)116.18 (89)
Vascular compressionVascular disorders9179.94 (91.07–355.52)179.53 (90.99–354.2)7.37 (5.32)165.67 (83.85)
Metastatic uterine cancerReproductive system and breast disorders4230.98 (82.29–648.34)230.74 (82.28–647.06)7.7 (4.84)208.33 (74.22)
Metastases to thoraxNeoplasms benign, malignant and unspecified (incl cysts and polyps)6171.01 (74.41–393.02)170.75 (74.38–391.96)7.31 (4.89)158.18 (68.82)
Vertebral column massMusculoskeletal and connective tissue disorders6162.35 (70.75–372.54)162.1 (70.73–371.54)7.24 (4.83)150.73 (65.69)
Metastases to chest wallMusculoskeletal and connective tissue disorders8140.24 (68.54–286.97)139.96 (68.49–286)7.04 (4.9)131.41 (64.22)
Autoimmune pancreatitisImmune system disorders10127.37 (67.24–241.25)127.05 (67.18–240.27)6.91 (4.97)119.96 (63.33)
pIK3CA-activated mutationCongenital, familial and genetic disorders7132.45 (61.69–284.37)132.22 (61.66–283.5)6.96 (4.71)124.56 (58.02)
Metastases to abdominal wallNeoplasms benign, malignant and unspecified (incl cysts and polyps)5150.5 (60.74–372.92)150.31 (60.72–372.05)7.13 (4.56)140.48 (56.69)
Resorption bone increasedMetabolism and nutrition disorders6128.26 (56.24–292.5)128.06 (56.22–291.7)6.92 (4.53)120.87 (53)
Breast cancer metastaticReproductive system and breast disorders9467.75 (55.04–83.39)66.15 (54–81.03)6 (5.32)64.19 (52.15)
Diabetic hyperosmolar comaEndocrine disorders6124.52 (54.64–283.78)124.33 (54.62–283.02)6.88 (4.49)117.54 (51.58)
Metastases to boneMusculoskeletal and connective tissue disorders14363.74 (53.81–75.5)61.45 (52.19–72.35)5.9 (5.34)59.76 (50.45)
Cystoid macular oedemaInjury, poisoning and procedural complications2874.95 (51.35–109.39)74.42 (51.13–108.34)6.17 (4.96)71.95 (49.3)
Metastases to lymph nodesBlood and lymphatic system disorders5465.42 (49.81–85.92)64.53 (49.32–84.44)5.97 (5.08)62.67 (47.72)
Labile hypertensionVascular disorders4135.65 (49.35–372.87)135.51 (49.35–372.12)6.99 (4.21)127.48 (46.38)
Vitreous adhesionsEye disorders3160.2 (49.54–518.07)160.08 (49.54–517.24)7.22 (4.13)148.98 (46.07)
dupuytren’s contractureMusculoskeletal and connective tissue disorders1186.56 (47.33–158.29)86.32 (47.28–157.59)6.38 (4.53)83 (45.39)
ClubbingCardiac disorders6107.78 (47.44–244.88)107.61 (47.42–244.22)6.68 (4.31)102.5 (45.11)
Hyperparathyroidism primaryMetabolism and nutrition disorders5114.9 (46.7–282.69)114.75 (46.69–282.03)6.77 (4.22)108.95 (44.28)
Lichen sclerosusSkin and subcutaneous tissue disorders791.82 (43.06–195.79)91.66 (43.04–195.19)6.46 (4.24)87.93 (41.24)
Metastases to breastReproductive system and breast disorders5104.76 (42.66–257.23)104.63 (42.66–256.62)6.64 (4.1)99.78 (40.64)
Hormone receptor positive breast cancerReproductive system and breast disorders691.61 (40.44–207.53)91.47 (40.43–206.97)6.46 (4.1)87.75 (38.74)
Retroperitoneal fibrosisImmune system disorders783.61 (39.27–178.04)83.47 (39.25–177.5)6.33 (4.11)80.36 (37.74)