| Infection-related organ dysfunction | Classic biomarkers | Elevated miRNAs (show significant association with biomarkers) | References |
| Acute respiratory distress syndrome (ARDS) | D-Dimer, PT, PLT%, IL-1β, TNF, IFN-γ, IL-6, IL-8, IL-10 [9, 25, 26] | miR-181, miR-101, miR-155, miR-320, miR-92, miR-93, miR-144, miR-34a | [30–35] | Systemic inflammatory response [1, 16, 21] | Ferritin, CRP, N/L, PT, Het/Alb, IL-1β, TNF, IFN-γ, IL-6, IL-8, IL-10 [9, 25, 26] | miR-223, miR-222, miR-126, miR-155, miR-320, miR-93, miR-142 | [33, 36–39] | Neutrophilia | Neutrophil count, WBC, N/L | miR-155, miR-320, miR-93, miR-146a, miR-221, miR-29, miR-21, | [30, 40–43] | Lymphocytopenia | Lymphocyte count, WBC, N/L, ferritin, IL-1β, TNF, IFN-γ, IL-6 [5, 25] | miR-155, miR-320, miR-93, miR-144, miR-223 | [33–36] | Thrombocytopenia | PLT count, PT, PDW, IL-1β, TNF, IFN-γ [25] | miR-126, miR-320, miR-223, miR-197, miR-191, miR-21, miR-96, miR-98 | [42, 44, 45] | Anemia | RBC, Hb, RDW, LDH, K+, IL-1β, TNF, IFN-γ [25] | miR-144, miR-320 | [46–49] | WBC count | Leukocyte count, N/L, Het/Alb | miR-150, miR-143, miR-223, miR-155, miR-320, miR-93 | [30, 33, 34, 36, 40, 42, 48–51] | Endothelial dysfunction [4, 17, 18] | PLT count, PT | miR-126, miR-223, miR-222, miR-34a | [33, 39] | Coagulation abnormalities (DIC, DVT, and multiorgan thrombosis) [7, 21, 22] | D-Dimer, PT, PLT% | miR-221, miR-222, miR-223, miR-146, miR-126, miR-155, miR-21, miR-320 | [31, 40, 42, 44, 45, 52, 53] | Cholangiocyte/bile duct dysfunction and hepatocyte damage [16, 17] | Alkaline-P, LDH, SGOT, SGPT, bilirubin | miR-122 (early), miR-34a, miR-193, miR-187-3p | [54, 55] | Kidney function impairment and injuries | Urea, Cr, Na+, K+, hypocalcaemia | miR-21, miR-210, miR-34, miR-92a, miR-93, miR-223 | [36, 56–59] | Myopathic changes, myofibril necrosis [19, 20] | CPK, LDH, SGOT, SGPT, urea, Cr | miR-133a, miR-155, miR-126, miR-206, miR-208a, miR-34 | [52, 60–62] |
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