Tumour Recurrence, Depth of Invasion, and Temple Location as Independent Prognostic Parameters of Lymph Node Metastases of Head and Neck Cutaneous Squamous Cell Carcinomas

Table 6

List of cSCC risk factors and their significance for incidence of metastases in our patients and in previously published studies.

Risk parameters	Our results of statistical analysis	Studies confirming a significant risk for incidence of metastases
T stage and tumour size	Significant	Haisma [8], Wermken [9], Thompson [10], Cherpelis [11], Clark [12], Rowe [26], Zeng [28], Jambusaria-Pahlajani [30], Lehnerdt [31], Quaedvlieg [32], Roozeboom [33]
Tumour recurrence	Significant	Wermken [9], Cherpelis [11], Moore [34]
Depth of infiltration	Significant	Haisma [8], Wermken [9], Thompson [10], Cherpelis [11], Brougham [16], Rowe [26], Leibovitch [27], Brantsch [35], Lehnerdt [31], Quaedvlieg [32], Roozeboom [33]
Subcutaneous infiltration	Significant	Wermken [9], Cherpelis [11], Clark [12], Jambusaria-Pahlajani [30], Moore [34], Quaedvlieg [32]
Positive resection margins	Significant	Wermken [9], Lee [36], Ch’ng [37], Quaedvlieg [32], Genders [38], Mourouzis [39],
Close resection margins	Not significant	Jenkins [40], Stratigos [41]
Poor differentiation	Not significant	Haisma [8], Wermken [9], Clark [12], Brougham [16], Vauterin [22], Rowe [26], Zeng [28], Jambusaria-Pahlajani [30], Karia [37], Lehnerdt [31], Moore [34], Quaedvlieg [32]
Desmoplastic type	Not evaluated	Breuninger [42]
Actinic keratosis	Not significant	Cherpelis [11], Rowe [26], Moore [34], Quaedvlieg [32], Del Regno [43]
Inflammation
Scarring
Irradiation
Temple location	Significant	Haisma [8], Thompson [10], Brougham [16]
Ear location	Not significant	Haisma [8], Wermken [9], Thompson [10], Rowe [26], Brantsch [35], Karia [44], Lehnerdt [31],
Perineural invasion	Not evaluated	Thompson [10], Cherpelis [11], Brougham [16], Rowe [26], Jambusaria-Pahlajani [30], Ch’ng [37], Karia [44], Moore [34], Quaedvlieg [32], Lin [45], Carter [46]
Angioinvasion	Not evaluated	Quaedvlieg [32]
Immunosuppression	Not evaluated	Cherpelis [11], Rowe [26], Venables [47], Tokez [48], Ch’ng [37]
Lymphatic invasion	Not evaluated	Moore [34]