Efficacy and Safety of Omeprazole for the Treatment of Acid Peptic Disorders: A Systematic Review and Meta-Analysis
Table 2
Incidence rate (per 100) of adverse events by the type of PPI and the placebo group.
Adverse events
Omeprazole
Esomeprazole
Ilaprazole
Lansoprazole
Pantoprazole
Rabeprazole
Placebo
At least one AE reporteda
11.0
0
17.0
6.7
20.1
17.1
30.9
Number of SAE reportedb
0.4
0
1.5
0
0.2
0.7
0.6
Most common types of AE reportedc
Headache
6.6
0
2.5
4.7
2.6
2.2
11.5
Diarrhea
6.0
4.9
1.9
0.7
5.9
2.2
4.9
Loss of appetite
4.3
0
1.2
0
0
0
0
Nausea
3.6
0
0
2.6
8.4
0
6.5
Constipation
1.6
0
0
4.5
0
0
4.4
Dizziness
1.6
0
0
4.1
0
0
2.7
Rash
1.1
0
0
1.8
5.0
3.0
0
Significantly different compared to omeprazole (), AE, adverse events. aData from 23 trials with overall AE rate data reported. bData from 15 trials with reported SAE data. cData from 19 trials with type of AE data.
