Efficacy and Safety of Omeprazole for the Treatment of Acid Peptic Disorders: A Systematic Review and Meta-Analysis

Table 3

Therapeutic effects of omeprazole in 4606 patients with nonerosive or erosive acid peptic disorders.

Factors	Nonerosive reflux disease (NERD) (n = 2286) (%)	Erosive disease (EO/ulcers) (n = 2320) (%)	value
Frequency of use
Number taking omeprazole (20 mg/d)	64	92
Duration omeprazole (4 weeks)	100	77
Response to omeprazole treatment
Healed with 20 mg/d omeprazole	59	77	<0.001
Median days to pain resolution^a	2-3 days	3-4 days	ns
Response time^b
At 1 week	nr	58.8
At 2 weeks	43.9	74	<0.0001
At 4 weeks	65.3	92.3
At 6 weeks	60	Nr	<0.0001
At 8 weeks	94.1	Nr
Resolution of pain by 4 weeks	90	89.7	ns
No nocturnal acid breakthrough	32	57	<0.001
H. pylori eradication	nr	87.3
Safety^c	6.1	16.4	<0.001

d, day; mg, milligram; nr, not reported; ns, not significant. ^aPain: NERD (dysphagia) or EO/ulcers (pain associated with ulcer or erosion). ^bResponse time: NERD (time to heartburn symptom resolution) or EO/ulcers (time to pain resolution), measured at two time periods during treatment. ^cSafety: number reporting at least one adverse event (mild moderate).