Efficacy and Safety of Omeprazole for the Treatment of Acid Peptic Disorders: A Systematic Review and Meta-Analysis
Table 3
Therapeutic effects of omeprazole in 4606 patients with nonerosive or erosive acid peptic disorders.
Factors
Nonerosive reflux disease (NERD) (n = 2286) (%)
Erosive disease (EO/ulcers) (n = 2320) (%)
value
Frequency of use
Number taking omeprazole (20 mg/d)
64
92
Duration omeprazole (4 weeks)
100
77
Response to omeprazole treatment
Healed with 20 mg/d omeprazole
59
77
<0.001
Median days to pain resolutiona
2-3 days
3-4 days
ns
Response timeb
At 1 week
nr
58.8
At 2 weeks
43.9
74
<0.0001
At 4 weeks
65.3
92.3
At 6 weeks
60
Nr
<0.0001
At 8 weeks
94.1
Nr
Resolution of pain by 4 weeks
90
89.7
ns
No nocturnal acid breakthrough
32
57
<0.001
H. pylori eradication
nr
87.3
Safetyc
6.1
16.4
<0.001
d, day; mg, milligram; nr, not reported; ns, not significant. aPain: NERD (dysphagia) or EO/ulcers (pain associated with ulcer or erosion). bResponse time: NERD (time to heartburn symptom resolution) or EO/ulcers (time to pain resolution), measured at two time periods during treatment. cSafety: number reporting at least one adverse event (mild moderate).