β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
Figure 2
Protection against STZ-induced hyperglycemia by β-cell specific overexpression of GPR39 in the tetGPR39/RIP-rtTA mice. (a) Nonfasting blood glucose levels measured twice a week. DOX was given in the drinking water to all four groups of animals from day 3. A group of tetGPR39/RIP-rtTA transgenic mice ( (red square), ) and a group of wild-type littermates ( (open square), ) were treated with low-dose STZ injections, 40 mg/kg daily from day 0 to day 4. A group of tetGPR39/RIP-rtTA transgenic mice ( (black circles), ) and a group of wild-type littermates ( (open circles), ), were mock treated with vehicle injections from day 0 to day 4. (b, c) At day 28, all animals were fasted for 18 hours before given access to food at time 0: the blood glucose (b) and insulin (c) were monitored at times indicated. *, *** (repeated measures (mixed model) ANOVA performed on versus ).
