β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
Figure 3
Effect of β-cell specific overexpression of GPR39 on oral glucose tolerance test (OGTT) after low-dose STZ treatment. (a) OGTT performed 35 days after STZ treatment (see Figure 2) in tetGPR39/RIP-rtTA transgenic (TG) mice with STZ treatment (red square) , in wild-type littermates (WT) with STZ treatment (open squares) , in WT mock-treated mice (open circles) , and in TG mock-treated mice (black circles) . ** (repeated measures (mixed model) ANOVA performed versus ). (b) area under the curve, *** (Mann-Whitney -test). a.u.: arbitrary units.
