β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia

Figure 4

Quantification of the β-cell area in pancreatic islets by immunohistochemistry. (a) WT mock-treated mice (empty bars − STZ) 𝑛=7 and tetGPR39/RIP-rtTA transgenic (TG) mock-treated mice (black filled bars − STZ) 𝑛=6. WT STZ treated (empty bars + STZ) 𝑛=5, tetGPR39/RIP-rtTA transgenic (TG) STZ-treated mice (red filled bars + STZ) 𝑛=5. *𝑃<0.05 (Mann-Whitney 𝑡-test). (b) Representative islets stained with anti-insulin (green) and anti-glucagon antibodies (red). a.u.: arbitrary units.

(a)

(b)