Liver Glucokinase<sub><b>A456V</b></sub> Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase

<table>Rat GK and GK<sub>A456V</sub> overexpression in the livers of STZ-treated mice. 60 <i>μ</i>g of pControl, pGK, or pGKA<sub>456V</sub> were hydrodynamically-transfected to diabetic mice. (a) GK protein content of liver homogenates was determined by Western blot. A representative blot and densitometric analysis is shown. (b) Further confirmation of GK overexpression was obtained by analysis of specific GK activity in liver extracts at different glucose concentration. Values are expressed as the means ± SE (<svg height="11.3125" id="M6" style="vertical-align:-0.1092pt" version="1.1" viewbox="0 0 42.5625 11.3125" width="42.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus pControl).</table>

International Journal of Endocrinology

fig1

Figure 1

Figure 1: Liver Glucokinase<sub><b>A456V</b></sub> Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase 

Figure 1 | Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase 