Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase
Figure 3
Blood glucose homeostasis in GK- and GKA456V-treated mice. Streptozotocin-induced diabetic mice were hydrodynamically injected with of pControl, pGK or pGKA456V. (a) Blood glucose levels were determined 48 h posttransfection in fed state and after a 5-hour fast. Values are the mean ± SE (–12, * versus pControl, § versus pControl and versus pGK). (b) Glucose tolerance test in overnight fasted, healthy mice transfected with pControl, pGK, or pGKA456V. **AUC versus pControl and pGK.
