Liver Glucokinase_A456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase

Figure 4

Effects of GK and GK_A456V overexpression on glycogen and glucose-6-phosphate DH activity in the liver. (a) Glycogen levels from fed and 5-hour fasted mice. (b) Glycogen balance between the fast and fed transition. (c) Glc6P DH activity was measured in liver extracts of mice in fed and fasted state. (d) Variation of Glc6P DH activity during the fed-to-fast transition. Data are mean ± SE. (𝑁=5–9. *𝑃<0.05 versus pControl; ^§𝑃<0.05 versus pControl and 𝑃<0.01 versus pGK; Δ𝑃<0.05 versus pControl and pGK).

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