Gamma Knife Radiosurgery for Acromegaly

Table 2

Adverse events of GKS for acromegaly.

Study	Hypopituitarism (%)	Headache (%)	Radiation necrosis (%)	Visual changes (%)
Iwai et al., 2010 [42]	2 (8)	1 (4)	1 (4)	0
Ronchi et al., 2009 [43]	—	—	—	0
Swords et al., 2009 [44]	3 (12)	0		0
Wan et al., 2009 [45]	6 (6)	—	2 (2)	0
Jagannathan et al., 2009 [46]	32 (34)	—	—	4 (4)
Losa et al., 2008 [47]	7 (9)	5 (6)	—	0
Pollock et al., 2008 [48]	16 (36)	—	—	1 (2)
Vik-Mo et al., 2007 [34]	14 (23)	—	—	—
Ježková et al., 2006 [49]	26 (43)	—	—	—
Castinetti et al., 2005 [50]	14 (17)	—	—	1 (1)
Kobayashi et al., 2005 [40]	39 (15)*	—	—	29 (11)*
Attanasio et al., 2003 [51]	2 (7)	1 (3)	—	0
Choi et al., 2003 [52]	0	—	—	0
Jane Jr. et al., 2003 [53]	18 (28)	—	—	—
Petrovich et al., 2003 [54]	2 (3)*	2 (3)*	—	3 (4)*
Ikeda et al., 2001 [55]	0	—	—	0
Fukuoka et al., 2001 [56]	0	—	—	0
Izawa et al., 2000 [57]	1 (3)	—	1 (3)	1 (3)
Shin et al., 2000 [58]	1 (6)*	—	—	1 (6)*
Zhang et al., 2000 [59]	—	—	—	—
Inoue et al., 1999 [60]	—	—	—	—
Kim et al., 1999 [61]	—	—	—	—
Kim et al., 1999 [62]	—	—	0	0
Mokry et al., 1999 [63]	3 (19)	—	—	0
Lim et al., 1998 [64]	1 (2)*	18 (28)*	—	1 (2)*
Martinez et al., 1998 [65]	0	—	—	1 (3)*
Morange-Ramosa et al., 1998 [66]	4 (16)*	—	—	1 (4)*
Pan et al., 1998 [67]	—	—	—	—
Park et al., 1996 [68]	0	—	0	0
Total (%)	191 (16)	27 (12)	4 (2)	43 (4)

*Numbers of GKS for all treated pituitary tumor types (not reported for acromegalic patients alone).