Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome
Table 1
Population characteristics.
All participants ()
Participants according to MetS status
Participants with MetS ()
Participants without MetS ()
Age (years), median (P25–P75)
56.0 (50.0–62.0)
56.0 (52.0–62.0)
58.0 (48.0–62.0)
0.790
Weight (kg), median (P25–P75)
80.0 (72.0–86.0)
82.0 (77.0–94.0)
75.0 (68.9–83.5)
<0.001
Height (cm), median (P25–P75)
179.0 (164.0–173.0)
170.0 (163.0–173.0)
169.0 (164.0–173.0)
0.799
BMI (kg/m2), median (P25–P75)
27.9 (25.2–30.5)
29.7 (27.7–31.4)
26.3 (24.4–28.3)
<0.001
Waist circumference (cm), median (P25–P75)
104.0 (97.0–111.0)
107.7 (103.0–113.5)
99.5 (95.0–106.0)
<0.001
Hormonal panel
Total testosterone (ng/mL), median (P25–P75)
4.5 (3.5–5.6)
4.0 (3.2–5.0)
5.1 (4.1–5.9)
0.001
Free calculated testosterone (ng/mL), median (P25–P75)
0.102 (0.074–0.156)
0.122 (0.074–0.653)
0.093 (0.075–0.113)
<0.001
SHBG (nmol/L), median (P25–P75)
35.8 (27.3–48.6)
33.6 (23.8–41.6)
40.2 (31.4–55.0)
0.003
LH (mUI/mL), median (P25–P75)
4.0 (2.7–5.9)
4.1 (3.1–7.6)
3.7 (2.6–5.4)
0.062
Estradiol (pg/mL), median (P25–P75)
28.5 (22.0–37.8)
26.0 (21.0–35.4)
31.0 (23.2–40.0)
0.164
FSH (mUI/mL), median (P25–P75)
5.0 (3.7–7.3)
5.1 (3.7–8.1)
4.6 (3.5–6.1)
0.164
TSH (U/mL), median (P25–P75)
1.3 (1.0–1.8)
1.3 (0.9–1.8)
1.3 (1.0–1.7)
0.634
T3 (pg/mL), median (P25–P75)
3.0 (2.8–3.3)
3.0 (2.8–3.3)
3.0 (2.7–3.3)
0.404
T4 (ng/dL), median (P25–P75)
1.0 (0.9–1.1)
1.1 (1.0–1.2)
1.0 (0.9–1.1)
0.040
Comorbidities
Hypogonadism, (%)
35.0 (23.2)
17 (23.0)
18.0 (23.4)
0.953
Hypothyroidism, (%)
0.0 (0.0)
0.0 (0.0)
0.0 (0.0)
—
Hyperthyroidism, (%)
1.0 (0.6)
0.0 (0.0)
0.0 (0.0)
—
Hyperprolactinemia, (%)
183 (8.2)
—
—
—
Alcohol intake, (%)
Absent
70.0 (61.9)
25.0 (67.6)
45.0 (59.2)
0.541
Frequent
41.0 (36.3)
12.0 (32.4)
29.0 (38.2)
Former intake
2.0 (1.8)
—
2.0 (2.6)
Smoking status, (%)
Never smoked
55.0 (36.7)
25.0 (33.8)
30.0 (39.5)
0.001
Smoker
32.0 (21.3)
9.0 (12.2)
23.0 (30.3)
Former intake
63.0 (42.0)
40.0 (54.0)
23 (30.3)
Participants with MetS versus participants without MetS. Data are expressed as the 25th percentile–the 75th percentile (P25–P75). Metabolic syndrome (MetS), body mass index (BMI), Sex-hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), free triiodothyronine (T3), and free thyroxine (T4).
