Clinical Study
Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes
Table 1
Comparison of characteristics among quartiles of HOMA insulin resistance index.
| | Variable | Quartiles of HOMA insulin resistance index | for trend | 1
Mean (SD) | 2
Mean (SD) | 3
Mean (SD) | 4
Mean (SD) |
| | Basic data | | | | | | | HOMA IR* | 1.7 (0.7) | 3.2 (0.4) | 4.9 (0.7) | 9.3 (3.2) | <0.001 | | Male/female | 19/17 | 12/24 | 19/17 | 15/21 | 0.55 | | Age, year | 60.5 (8.9) | 60.5 (9.3) | 56.4 (10.0) | 54.3 (11.8) | 0.003 | | FH*, yes/no | 21/15 | 19/17 | 18/18 | 17/18 | 0.45 | | G*, mg/day | 166.9 (45.0) | 182.2 (41.1) | 175.6 (46.1) | 173.7 (30.6) | 0.66 | | M*, mg/day | 1648.6 (628.9) | 1779.2 (601.7) | 1784.7 (611.8) | 1577.1 (583.8) | 0.65 | | BMI*, kg/m2 | 24.8 (2.9) | 24.8 (2.8) | 26.6 (5.3) | 28.5 (4.5) | <0.001 | | WC*, cm | 83.6 (7.6) | 83.4 (7.8) | 87.3 (9.1) | 93.0 (10.4) | <0.001 | | HC*, cm | 93.8 (5.9) | 93.9 (6.9) | 96.2 (8.6) | 99.8 (8.7) | 0.002 | | SBP*, mmHg | 131.9 (16.0) | 135.9 (18.8) | 136.3 (15.6) | 139.3 (13.0) | 0.07 | | DBP*, mmHg | 77.4 (7.8) | 79.5 (10.9) | 80.8 (9.6) | 80.5 (9.7) | 0.002 | | MSC, yes % | | | | | | | LWC | 42.9 | 44.4 | 50.0 | 85.7 | <0.001 | | HTN | 14.3 | 30.6 | 33.3 | 45.7 | 0.006 | | HTG | 25.7 | 36.1 | 44.4 | 62.9 | 0.001 | | LHDL | 51.4 | 75.0 | 58.3 | 65.7 | 0.484 | | Fasting serum factors | | | | | | | Glucose, mg/dL | 169.3 (57.2) | 184.5 (48.6) | 198.2 (47.5) | 223.6 (63.0) | <0.001 | | HbA1c, % | 8.7 (1.5) | 8.7 (1.6) | 9.4 (1.8) | 9.8 (1.3) | 0.001 | | Insulin, IU/mL | 4.6 (2.5) | 7.4 (1.9) | 10.8 (4.0) | 17.5 (5.9) | <0.001 | | Adiponectin, μg/mL | 19.1 (7.7) | 18.0 (7.0) | 15.3 (7.7) | 15.0 (6.2) | 0.006 | | Fasting lipoprotein | | | | | | | Triglyceride, mg/dL | 130.9 (85.3) | 155.7 (95.3) | 189.3 (223.8) | 270.4 (404.6) | 0.01 | | Cholesterol, mg/dL | 172.8 (33.9) | 174.9 (40.1) | 171.8 (30.3) | 194.9 (48.4) | 0.03 | | HDL, mg/dL | 43.7 (8.9) | 45.2 (9.8) | 41.9 (8.3) | 42.8 (9.6) | 0.40 | | LDL, mg/dL | 111.8 (30.8) | 108.4 (33.2) | 106.8 (30.9) | 121.8 (36.6) | 0.25 |
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HOMA IR: HOMA insulin resistance index; FH: family history of type 2 diabetes disease; G: gliclazide; M: metformin; BMI: body mass index; WC: waist circumference; HC: hip circumference; SBP: systolic blood pressure; DBP: diastolic blood pressure; LWC: large waist circumference; HTN: high blood pressure; HTG: high triglyceride; LHDL: low HDL-cholesterol; HDL: HDL-cholesterol; LDL: LDL-cholesterol.
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